2012 Fiscal Year Final Research Report
Molecular and morphological studies on roles of autophagy in tick starvation periods and their transmission of protozoan parasites.
| Project/Area Number |
22580356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
白藤 梨可 帯広畜産大学, 原虫病研究センター, 助教 (00549909)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マダニ媒介性疾病 / フタトゲチマダニ / ピロプラズマ / 生存戦略 / 節足動物 |
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| Research Abstract |
Ticks can feed a blood meal from most vertebrates except for fish and ingest a large amount of blood from hosts. Additionally, they seem to have a unique strategy to endure the off-host state for a long period. Autophagy is induced by starvation condition and is essential for life-span extention, therefore we speculate that autophagy also occurs in ticks. Some autophagy-related genes were isolated in Haemaphysalis longicornis, the most dominant tick in Japanese pastures and vector of piroplasmosis among grazing cattle, and then they were expressed during their unfed and moulting periods. It showed that autophagy plays an important role in tick suvival during long starvation periods.
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[Journal Article] Autophagy and its physiological relevance in arthropods: Current knowledge and perspectives2010
Author(s)
Malagoli, D., F. C. Abdalla, Y. Cao, Q. Feng, K. Fujisaki, A. Gregorc, T. Matsuo, I. P. Nezis, I. S. Papassideri, M. Sass, E. C. Silva-Zacarin, G. Tettamanti and R. Umemiya-Shirafuji
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Journal Title
Autophagy
Volume: 6
Pages: 575-588
DOI
Peer Reviewed
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