Evaluation of effect for insulin signaling and insulin resistance in feline obesity.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22580370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: SAKO Toshinori 日本獣医生命科学大学, 獣医学部, 教授 (70153971)
• Co-Investigator(Kenkyū-buntansha): MORI Akihiro (60549559)
• Project Period (FY): 2010 – 2012
• Keywords: 糖尿病 / 猫 / インスリン / 人工膵臓 / インスリン抵抗性

Research Abstract

This study suggested feline obesity induce decreased expression of insulin signaling and it leads insulin resistance. Also, high carbohydrate diet induces high insulin response in obese cats.

Research Products

• [Journal Article] Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats. (2011)
  • Author(s): Lee P, Mori A, Takemitsu H, Yamamoto I, Arai T.
  • Journal Title: Vet J. Volume: Vol 190 Pages: e150-153
  • DOI: doi:10.1016/j.tvjl.2011.04.003.
  • Peer Reviewed
• [Journal Article] Evaluation of artificial pancreas technology for continuous blood glucosemonitoring in dogs. (2011)
  • Author(s): Mori A, Lee P, Yokoyama T, Oda H, Saeki K, Miki Y, Nozawa S, Azakami D, Momota Y, Makino Y, Matsubara T, Osaka M, Ishioka K, Arai T, Sako T.
  • Journal Title: J Artif Organs Volume: Vol 14 Pages: 133-139
  • DOI: doi:10.1007/s10047-011-0560-1.
  • Peer Reviewed
• [Journal Article] Hypertriglyceridemia with increased plasma insulin concentrations in cats. (2010)
  • Author(s): Hatano Y, Mori N, Asada M, Mori A, Yamamoto I, Muranaka S, Kojima M, Kigure M, Yagishita M, Sako T, Arai T.
  • Journal Title: Res Vet Sci. Volume: Vol 88 Pages: 458-460
  • DOI: doi:10.1016/j.rvsc.2009.12.012.
  • Peer Reviewed
• [Journal Article] Impact ofCommercially Available Diabetic Prescription Diets on Short-Term Post-PrandialSerum Glucose, Insulin, Triglyceride and Free Fatty Acid Concentrations of Obese Cats.
  • Author(s): Mimura K, Mori A, Lee P, Ueda K, Oda H, Saeki K, Arai T, Sako T.
  • Journal Title: J Vet Med Sci
  • URL: http://dx.doi.org/10.1292/jvms.12-0310
  • Peer Reviewed
• [Presentation] 肥満猫に対する糖尿病療法食が血清グルコースおよびインスリン濃度に与える影響について
  • Author(s): 上田香織、出雲梨花子、三村可菜、岡本理沙、木村友子、佐伯香織、小田民美、森昭博、左向敏紀
  • Organizer: 第14回日本ペット栄養学会