2012 Fiscal Year Final Research Report
Synthesis of Biaryl Type Natural Organic Molecules
| Project/Area Number |
22590003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
ABE Hitoshi 富山大学, 大学院・理工学研究部(工学), 教授 (70221728)
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| Project Period (FY) |
2010 – 2012
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| Keywords | クロスカップリング / パラジウム / 天然物合成 / 天然物合成 |
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| Research Abstract |
Many organic compounds which possess a biaryl skeleton were found from the nature, and some exhibit interesting biological activities. However, there have been a few methods for the synthesis of highly functionalized biaryl molecules. Recently, a palladium-mediated intramolecular coupling reaction has been recognized as the useful technique for the construction of such compounds. In this study, we developed the synthetic methods for biaryl-type molecules, and performed the total synthesis of several natural products.
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