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2012 Fiscal Year Final Research Report

Structural diversity of compounds isolated from subtropical plants and their biological activity

Research Project

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Project/Area Number 22590006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHiroshima University

Principal Investigator

OTSUKA Hideaki  広島大学, 大学院・医歯薬保健学研究院, 名誉教授 (00107385)

Co-Investigator(Kenkyū-buntansha) MATSUNAMI Katsuyoshi  広島大学, 大学院・医歯薬保健学研究院, 教授 (70379890)
SUGIMOTO Sachiko  広島大学, 大学院・医歯薬保健学研究院, 助教 (60549012)
Project Period (FY) 2010 – 2012
Keywords生薬 / 天然物化学 / 生理活性
Research Abstract

Many new compounds were isolated from the plants harvested in Okinawa, Thai. , India and Madagascar. Their structures including absolute structures were elucidated using various kinds of spectroscopic data. Biological assays were performed toward isolated compounds

  • Research Products

    (42 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] 6'-O-(2"S,3R")-2"-Ethyl-2",3"-dihydroxy- butyrates of aliphatic alcohol ・-D-glucosides from the branches of Microtropis japonica2012

    • Author(s)
      Y. Uemura, S. Sugimoto, K.Matsunami, H. Otsuka, Y., Takeda, M. Kawahata K. Yamaguchi, Microtropins AI
    • Journal Title

      Phytochemistry

      Volume: 87 Pages: 132-136

    • Peer Reviewed
  • [Journal Article] Lhieochaiphant, Oblongionosides AF, megastigmane glycosides from the leaves of Croton oblongifoliusRoxburgh2012

    • Author(s)
      Y. Takeshige, S. Kawakami, K. Matsunami, H.Otsuka, D. and S
    • Journal Title

      Phytochemistry

      Volume: 80 Pages: 132-136

    • Peer Reviewed
  • [Journal Article] Medicinal plants of Thailand. II Chemical studies on the seed kernels ofEntada rheedei Sprengel2012

    • Author(s)
      S. Sugimoto, K. Matsunami H. Otsuka
    • Journal Title

      Journal of Natural Medicines

      Volume: 66 Pages: 552-557

    • Peer Reviewed
  • [Journal Article] Entadosides AD, triterpene saponins and a glucoside of the sulphur-containing amide from the kernel nuts of Entada phaseoloides(L.) Merrill2012

    • Author(s)
      Y. Iwamoto, S. Sugimoto, L.Harinantenaina, K. Matsunami, H. Otsuka
    • Journal Title

      Journal of Natural Medicines

      Volume: 66 Pages: 321-328

    • Peer Reviewed
  • [Journal Article] Annonamine, a new aporphine alkaloid from the leaves of Annona muricata2012

    • Author(s)
      A. Matsushige, Y. Kotake, K. Matsunami, H. Otsuka, S. Ohta, Y. Takeda
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 60 Pages: 257-259

    • Peer Reviewed
  • [Journal Article] Three new megastigmanes from the leaves of Annona muricata2012

    • Author(s)
      A. Matsushige, K. Matsunami, Y. Kotake, H. Otsuka, S. Ohta
    • Journal Title

      Journal of Natural Medicines

      Volume: 66 Pages: 284-291

    • Peer Reviewed
  • [Journal Article] A new iriDOI:d glycoside and NO production inhibitory activity of compounds, isolated from Russelia equisetiformis2012

    • Author(s)
      M. Ochi, K. Matsunami, H. Otsuka, Y. Takeda
    • Journal Title

      Journalof Natural Medicines

      Volume: 66 Pages: 227-232

    • Peer Reviewed
  • [Journal Article] Symplocosionosides A-C,three megastigmane glycosides, a neolignan glucoside, and triterpene glycosyl esters fromthe leaves of Symplocos cochinchinensisvar.philippinensis2012

    • Author(s)
      W.-H. Cai, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda
    • Journal Title

      American Journal of Plant Sciences

      Volume: 2 Pages: 609-618

    • Peer Reviewed
  • [Journal Article] Myrseguinosides A-E, five new glycosides from the fruits of Myrsine seguinii2011

    • Author(s)
      K. Matsunami, H. Otsuka, Y. Takeda
    • Journal Title

      Chemicaland Pharmaceutical Bulletin

      Volume: 59 Pages: 1274-1280

    • Peer Reviewed
  • [Journal Article] Tareciliosides H-M: Further cycloartane glycosides from the leaves of Tarenna gracilipes2011

    • Author(s)
      Z. Zhao, K. Matsunami, H. Otsuka. T. Shinzato, Y. Takeda
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 59 Pages: 902-905

    • Peer Reviewed
  • [Journal Article] Medicinal plants of Thailand. I Structures of rheedeiosides A-D and cis-entadamide A ・-Dglucopyranoside from the seed kernels of Entada rheedei2011

    • Author(s)
      S. Sugimoto, K. Matsunami, H. Otsuka
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 59 Pages: 466-471

    • Peer Reviewed
  • [Journal Article] A glycerol α-D-glucronide and a megastigmane glycoside from the leaves of Guettarda speciosaL2011

    • Author(s)
      W.-H. Cai, K. Matsunami, H. Otsuka, T.Shinzato, Y. Takeda
    • Journal Title

      Journal of Natural Medicines

      Volume: 65 Pages: 364-369

    • Peer Reviewed
  • [Journal Article] megastigmane gentiobioside, sulfatricalysines A-F and ent-kaurane glucosides, tricalysiosides X-Z from the leaves of Tricalysia dubia(Lindl.) Ohwi2011

    • Author(s)
      J. Shitamoto, S. Sugimoto, K. Matsunami, H. Otsuka, T. Shinzato, Y. Tadeda,Tricalysionoside A
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Pages: 72-77

    • Peer Reviewed
  • [Journal Article] Crotonionosides A-G: Megastigmane glycosides from the leaves of Croton cascarilloidesRauschel2011

    • Author(s)
      S. Kawakami, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda
    • Journal Title

      Phytochemistry

      Volume: 72 Pages: 147-153

    • Peer Reviewed
  • [Journal Article] Schefflerin A-G: New triterpene glucosides from the leaves of Schefflera arboricola2010

    • Author(s)
      Z. Zhao, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda, M. Kawahata, K.Yamaguchi
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 58 Pages: 1343-1348

    • Peer Reviewed
  • [Journal Article] 5-Alkylresorcinol glucosides from the leaves of Grevillea robustaA. Cunn2010

    • Author(s)
      Y. Yamashita, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda
    • Journal Title

      Journal of Natural Medicines

      Volume: 64 Pages: 474-477

    • Peer Reviewed
  • [Journal Article] Megastigmane glucosides and unusual monoterpenefrom the leaves of Cananga odoratavar. odorata,and absolute structures of related megastigmane glucosides isolated from C. odoratavar. odorata and Breyniaofficinalis2010

    • Author(s)
      K. Matsunami, J. Nagashima, S. Sugimoto, H. Otsuka, Y. Takeda, D. Lhieochaiphant, S. Lhieochaiphant
    • Journal Title

      Journal of Natural Medicines

      Volume: 64 Pages: 460-467

    • Peer Reviewed
  • [Journal Article] Lhieochaiphant, Canangafruticosides A-E: Five monoterpene glucosides, two monoterpenes and a monoterpene glucoside diester of thearyldihydronaphthalene lignan dicarboxylic acid from leaves of Cananga odoratavar. Fruticosa2010

    • Author(s)
      J. Nagashima, K. Matsunami, H. Otsuka, D. Lhieochaiphant, S
    • Journal Title

      Phytochemistry

      Volume: 71 Pages: 1564-1572

    • Peer Reviewed
  • [Journal Article] crotofolane-type diterpenoid and a rearranged nor-crotofolane-type diterpenoid with a new skeleton from the stems of Croton cascarilloides2010

    • Author(s)
      S. Kawakami, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda, M. Kawahata, K. Yamaguchi
    • Journal Title

      Tetrahedron Letters

      Volume: 51 Pages: 4320-4322

    • Peer Reviewed
  • [Journal Article] Microtropiosides A-G: ent-Labdane diterpenoid glucosides fromleaves of Microtropis japonicaHallier f2010

    • Author(s)
      Y. Koyama, K. Matsunami, H. Otsuka, T. Shinzato, Y. Takeda
    • Journal Title

      Phytochemistry

      Volume: 71 Pages: 675-681

    • Peer Reviewed
  • [Presentation] ナンバンアワブキ葉部の成分研究(2)2013

    • Author(s)
      上村有加、岩見美緒、杉本幸子、松浪勝義、大塚 英昭、武田美雄
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜、神奈川
    • Year and Date
      2013-03-28
  • [Presentation] 熱帯・亜熱帯植物の活性成2012

    • Author(s)
      大塚英昭
    • Organizer
      日本生薬学会 第59回年会(招待講演)
    • Place of Presentation
      木更津、千葉
    • Year and Date
      2012-09-17
  • [Presentation] Crotofolanes, rare diterpenoids from Croton cascarilloides2012

    • Author(s)
      S. Kawakami, K. Matsunami, H. Otsuka
    • Organizer
      The 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy
    • Place of Presentation
      Seoul, Republic of Korea
    • Year and Date
      2012-08-24
  • [Presentation] Triterpene saponins from seed kernel of Entada phaseoloidesand E. rheedeiand their cytotoxicity2012

    • Author(s)
      H. Otsuka, S. Sugimoto, K. Matsunami
    • Organizer
      The 2nd Current Drug Development International Conference
    • Place of Presentation
      Phuket, Kingdom of Thailand
    • Year and Date
      2012-05-02
  • [Presentation] グミモイドキより得た稀な構造のジテルペン類およびその生理活性2012

    • Author(s)
      川上晋、松浪勝義、大塚英昭、武田美雄
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] モクレイシ(Microtropis japonicaHallier f,)葉部の成分研究(3)2012

    • Author(s)
      寺澤沙織、杉本幸子、松浪勝義、大塚英昭、武田美雄
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] シナモスマ・フラグランスより得れた新規drimane型セスキテルペン2012

    • Author(s)
      野本裕也、杉本幸子、松浪勝義、大塚英昭
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] シシアクチ葉部からの新規ベンゾキノン誘導体を地位新とした成分研究(2)2012

    • Author(s)
      浅海慎太郎、杉本幸子、松浪勝義、武田美雄
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] イランイランノキ(Cananga odoroatavar. odorata)の新規リグナン誘導体研究2012

    • Author(s)
      勝井美果、杉本幸子、松浪勝義、大塚英昭
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] Chemical constituents from the leaves of Cananga odoratavar. Fruticosa2011

    • Author(s)
      H. Otsuka
    • Organizer
      6th CCTCNM-KSP-JSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      瀋陽(中華人民共和国)
    • Year and Date
      2011-10-22
  • [Presentation] Novel diterpenoids fromCroton cascarilloide2011

    • Author(s)
      S. Kawakami, K. Matsunami, H.Otsuka, Y. Takeda
    • Organizer
      6th CCTCNM-KSP-JSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      瀋陽(中華人民共和国)
    • Year and Date
      2011-10-21
  • [Presentation] Chemicalconstituents from the leaves of Microtropis jJaponica2011

    • Author(s)
      S. Terazawa, Y. Koyama, S. Sugimoto, K. Matsunami, H. Otsuka, Y. Takeda,M. Kawahata, K. Yamaguchi
    • Organizer
      6th CCTCNM-KSP-JSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      瀋陽(中華人民共和国)
    • Year and Date
      2011-10-21
  • [Presentation] Acylated glucosides of the stems of Microtropis japonica2011

    • Author(s)
      Y. Uemura, S. Sugimoto, K. Matsunami, H. Otsuka, Y. Takeda
    • Organizer
      6th CCTCNM-KSP-JSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      瀋陽(中華人民共和国)
    • Year and Date
      2011-10-21
  • [Presentation] シシアクチからの新規ベンゾキノン誘導体を中心とした成分研究2011

    • Author(s)
      浅海慎太郎、杉本幸子、松浪勝義、武田美雄
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
  • [Presentation] シマニシキソウ(Euphorbia hirta)全草の成分研究2011

    • Author(s)
      野本裕也、杉本幸子、松浪勝義、大塚英昭、武田美雄
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
  • [Presentation] モクレイシ葉部の成分研究(2)2011

    • Author(s)
      寺澤沙織、上村有加、小山裕加、杉本幸子、松浪勝義、大塚英昭、武田美雄
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
  • [Presentation] Labdane-type diterpeneglucosides and acylated glucosides of Microtropis japonica、2010

    • Author(s)
      Y. Uemura, Y. Koyama, K. Matsunami, H. Otsuka, Y. Takeda
    • Organizer
      JSPS-NRCT Core University Progarm on Natural Medicine in Pharmaceutical Science
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2010-12-09
  • [Presentation] New crotofolane-type diterpenoidsfrom Croton cascarilloidesRauschel2010

    • Author(s)
      S. Kawakami, K. Matsunami, H. Otsuka,Y. Takeda
    • Organizer
      JSPSNRCT Core University Progarm on Natural Medicine in Pharmaceutical Science
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2010-12-09
  • [Presentation] Absolute stereochemistry of megastigmane glucosides from Macaranga tanarius2010

    • Author(s)
      K. Matsunami, H. Otsuka, Y. Takeda
    • Organizer
      JSPS-NRCTCore University Progarm on Natural Medicine in Pharmaceutical Science
    • Place of Presentation
      Bangkok, Thailan
    • Year and Date
      2010-12-09
  • [Presentation] N-Acetylglucosamine containing saponins fromEntada rheedei2010

    • Author(s)
      S. Sugimoto, K. Matsunami, H. Otsuka
    • Organizer
      JSPS-NRCT Core University Progarm on Natural Medicine in Pharmaceutical Sciences. The Ninth Joint Seminar
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2010-12-08
  • [Presentation] Sulfated glucosides fromthe leaves of Tricalysia dubia2010

    • Author(s)
      H. Otsuka, J. Shitamoto, K. Matsunami, Y. Takeda
    • Organizer
      JSPS-NRCT Core University Progarm on NaturalMedicine in Pharmaceutical Sciences. The Ninth Joint Seminar
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2010-12-08
  • [Remarks]

    • URL

      HTTP://WWW6.ocn.ne.jp/~hidjun

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Published: 2014-08-29  

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