2012 Fiscal Year Final Research Report
Development of Catalytic Synthetic Reactions with High Clark Number Elements (Without A small Amounts of Rare Metals)
| Project/Area Number |
22590008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
KONDO Kazuhiro 名古屋市立大学, 大学院・薬学研究科, 准教授 (90277343)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 触媒的合成反応 / 有機化学 / クラーク数 / アリール化 / シアノシリル化 / ヒドロシリル化 / N-複素環カルベン / Duphos |
|---|
| Research Abstract |
1) The Ni-catalyzed asymmetric arylation of benzaldehydes bearing an ortho-masked H group with potassium aryltriolborates has been developed. The keys to success were (i) steric tuning of benzaldehyde derivatives bearing an ortho-Me2PhSi group, and (ii) the use of potassium arylborates as aryl sources.
2) A method for cyanation reaction of carbonyl and imino compounds with trimethylsilyl cyanide in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6,-trimethylphenyl)imidazolium chloride and potassium tert-butoxide. has been developed.
|
