2012 Fiscal Year Final Research Report
Development of novel synthetic method and its use for synthesis of natural products
| Project/Area Number |
22590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Koji 北海道医療大学, 薬学部, 講師 (80272962)
ABE Takumi 北海道医療大学, 薬学部, 助教 (80453273)
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| Project Period (FY) |
2010 – 2012
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| Keywords | インドールアルカロイド / 有機金属試薬 / クロスカップリング / インドリルボレート / ホウ素 / 抗腫瘍活性 |
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| Research Abstract |
Cross-coupling reaction of indolylborate was used for concise total synththesis of calothrixins A and B. Unprecedented use of CuOTf for 6π-electrocyclization was also found, which was successfully applied for the improved synthesis of ellipticine. Introduction of aryl substituents to bicyclic lactam ABH was performed by metal-catalyzed coupling process.
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[Journal Article] Hibino, Enantioselective total synthesis of 1,3-disubstituted ・-carboline alkaloids, (-)-dichotomine A and (+)-dichotomide II2013
Author(s)
S. Tagawa, T. Choshi, A. Okamoto, T. Nishiyama, S. Watanabe, N. Hatae, M. Ishikura, S
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Journal Title
Eur. J. Org. Chem
Pages: 1805-1810
DOI
Peer Reviewed
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[Journal Article] Hibino2012
Author(s)
K. Matsumoto, T. Choshi, M. Horai, Y. Zamami, K. Sasaki, T. Abe, M. Ishikura, N. Hatae, T. Iwamura, S. Tohyama, J. Nobuhiro, S
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 22
Pages: 4762
Peer Reviewed
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[Presentation] Metal-catalyzed arylation of ABH2010
Author(s)
T. Abe, H. Takeda, K. Yamada, M. Ishikura
Organizer
XXIVth European Colloquium on Heterocyclic Chemistry
Place of Presentation
Vienna University of Technology, Vienna, Austria
Year and Date
20100823-27
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