2012 Fiscal Year Final Research Report
Synthetic Studies on Structurally Novel Antitumor Natural Products, Hederacines
| Project/Area Number |
22590020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
AOYAGI Sakae 東京薬科大学, 薬学部, 教授 (30212385)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 合成化学 / 天然物合成化学 |
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| Research Abstract |
Hederacines A and B, isolated from Glechoma hederaceae, have structurescontaining anuniqueaza-tricycles and show moderate levels of cytotoxicity. In this study, racemic syntheses of 9-epi-hederacine A and 9-epi-hederacine B were achieved via a potential common intermediateprecursor.
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