2012 Fiscal Year Final Research Report
New Synthetic Methods for the Construction of Organic Molecules Based on the Chemistry of Magnesium Carbenoids
| Project/Area Number |
22590021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | カルベン / カルベノイド / マグネシウムカルベノイド / 有機マグネシウム / スルホキシド / 有機合成 / 不斉合成 / スルホキシド‐マグネシウム交換反応 |
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| Research Abstract |
Carbenes and carbenoids have been known to be highly reactive carbon species that show a variety of unique reactivities. However, those reactive species are not fully used in organic synthesis. In order to solve the problem mentioned above, we used aryl α-haloalkyl (or alkenyl) sulfoxides as the precursors and used sulfoxide-magnesium exchange reaction for generation of much mild magnesium carbenoids (alkylmagnesium carbenoids, magnesium alkylidenecarbenoids, cyclopropylmagnesium carbenoids and cyclobutylmagnesium carbenoids). From the investigation of their nature and reactivity, a variety of novel new synthetic reactions were found and established. In addition, it was established that the method for a synthesis of aryl α-chloroalkyl sulfoxides in optically active form. New asymmetric synthesis of organic molecules was successfullyobtained by using these optically active α-chloroalkyl sulfoxides.
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Research Products
(17 results)
