2013 Fiscal Year Final Research Report
New deployment of the synthetic method utilized the characteristic of radical species
| Project/Area Number |
22590026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
MIYABE HIDETO 兵庫医療大学, 薬学部, 教授 (10289035)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 有機化学 / 合成化学 / ラジカル / 連続反応 / ルイス酸 / 酸化チタン |
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| Research Abstract |
The cascade or sequential reactions based on radical chemistry were investigated. I found that the sequential reaction of the intermediates arynes, generated from benzynes and formamides, with dialkylzinc proceeded. Next, I found that the cascade radical reactions, starting from the polarity-mismatched perfluoroalkyl radical addition to an electron-deficient acceptor, proceeded effectively. These reactions proceeded with good enantioselectivities by employing chiral Lewis acid. Additinally, the synthetically useful photocatalytic reduction of ketones was developed by using titanium dioxide.
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