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2012 Fiscal Year Final Research Report

Creation of tailor-made immobilized artificial enzymes

Research Project

  • PDF
Project/Area Number 22590027
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionGunma University

Principal Investigator

HIOKI Hideaki  群馬大学, 教育学部, 教授 (00208737)

Project Period (FY) 2010 – 2012
Keywordsカリックスアレーン / 触媒 / コンビナトリアル化学
Research Abstract

Effective method for the creation of immobilized tailor-made catalysts possessing high reaction efficiency and substrate specificity like enzymes was investigated. Peptidocalixarene library, which has four arms consisting two kinds of peptides on the upper rim was synthesized. The library consists ca 100000 members. Exploring the highly reactive catalyst in the library is now under investigation.

  • Research Products

    (7 results)

All 2013 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Solid-phase synthesis of benzothiazoles using an alkoxyamine linker2012

    • Author(s)
      Hideaki Hioki, Kimihito Matsushita, Takeshi Noda, Kota Yamaguchi, Miwa Kubo, Kenichi Harada, Yoshiyasu Fukuyama
    • Journal Title

      Tetrahedron Lett

      Volume: vol. 53, No. 33 Pages: 4337-4342

    • Peer Reviewed
  • [Journal Article] Synthesis of the ABC ring system of Jiadifenin via Pd-catalyzed cyclizations2011

    • Author(s)
      Kenichi Harada, Akiko Imai, Kazuharu Uto, Rich G. Carter, Miwa Kubo, Hideaki Hioki, Yoshiyasu Fukuyama
    • Journal Title

      Org. Lett

      Volume: vol. 13, No.5 Pages: 988-991

    • Peer Reviewed
  • [Journal Article] Novel alkoxyamine linker to load ketones for solid-phase synthesis: Application of the synthesis of 1,4-benzodiazepine-2-ones2010

    • Author(s)
      Kimihito Matsushita, Chieko Okamoto, Mayumi Yoshimoto, Kenichi Harada, Miwa Kubo, Yoshiyasu Fukuyama, Hideaki Hioki
    • Journal Title

      J. Comb. Chem

      Volume: vol. 12, No. 3 Pages: 311-314

    • Peer Reviewed
  • [Presentation] アルコキシアミンリンカーを用いたベンズアゾール類の固相合成法の開発2013

    • Author(s)
      山口滉太,樋口優介,日置英彰
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2013-03-30
  • [Presentation] 基質をオキシムとして担持するアルコキシアミンリンカーを用いたベンズアゾール類の固相合成法の開発2011

    • Author(s)
      山口滉太,樋口優介,松下公人,原田研一,久保美和,福山愛保,日置英彰
    • Organizer
      日本化学会関東支部群馬地区地域懇談会
    • Place of Presentation
      群馬大学工学部(群馬県)
    • Year and Date
      2011-12-10
  • [Presentation] アルコキシアミンリンカーを用いたベンゾジアゼピン類の固相コンビナトリアル合成2011

    • Author(s)
      新井逸実,樋口優介,松下公人,原田研一,久保美和,福山愛保,日置英彰
    • Organizer
      日本化学会関東支部群馬地区地域懇談会
    • Place of Presentation
      群馬大学工学部(群馬県)
    • Year and Date
      2011-12-10
  • [Presentation] アルコキシアミンリンカーを用 いたベンゾジアゼピン類の固相コンビナ トリアル合成とその抗マラリア活性2010

    • Author(s)
      松下公人,原田研一,久保美和,福山愛保, 日置英彰
    • Organizer
      第60回有機合成化学協会関東支部シンポジ ウム
    • Place of Presentation
      新潟薬科大学(新潟県)
    • Year and Date
      2010-12-04

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Published: 2014-08-29  

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