2012 Fiscal Year Final Research Report
Development of efficientmethod to convert molecular structure utilizing new Mitsunobu reaction and kineticmol ecul arrecognition
| Project/Area Number |
22590032
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
TSUNODA Tetsuto 徳島文理大学, 大学院・薬学研究科, 教授 (00172049)
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA Mitsuyo 徳島文理大学, 大学院・薬学研究科, 助教 (50148772)
KAKU Hiroto 徳島文理大学, 大学院・薬学研究科, 講師 (90299339)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 新光延試薬 / 不斉分子認識 / デラセミ化 / 不斉全合成 / アンチマイシン / アブラムシ色素 |
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| Research Abstract |
We developed efficient method to convert molecular structure utilizing newMitsunobu reaction and kinetic molecular recognition. For example, the use of host molecule withalkaline converted racemic 3-benzy-2-hexanone and to the S-isomer of 99% ee in 93% yield.Furthermore, new Mitsunobu reagents such as CMBP and CMMP prepared were mediated C-C and C-Nforming reaction in excellent yield. Utilizing these new reaction, we synthesized biologically activenatural products.
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[Journal Article] Viridaphin A1 Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda.2011
Author(s)
M.Horikawa, T. Hoshiyama, M. Matsuzawa, T.Shugyo, M. Tanaka, S. Suzuki, M. Sato, T. Ito, Y. Asakawa, H. Kaku, T. Nishii, M. Inai, S. Takahashi, T. Tsunoda
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Journal Title
J. Nat. Prod.
Volume: 74
Pages: 1812-1816
DOI
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[Presentation] Fries転位を基盤としたナフトール系アフブラムシ色素の合成.2012
Author(s)
西村太一,岩田岳城,前川弘典,西井健,曽我部彩香,松々迫順雅,稲井誠,伊藤卓也,鈴木真也,島津光明,竹林純,八木康行,堀川美津代,加来裕人,角田鉄人
Organizer
第38回反応と合成の進歩シンポジウム
Place of Presentation
東京.
Year and Date
20121100
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[Presentation] アブラムシに含まれる色素の構造と生物活性.2012
Author(s)
堀川美津代,相部真希,星山東燮,松澤雅子,修行孝典,田中正己,鈴木真也,島津光明,高橋滋,加来裕人,角田鉄人
Organizer
第54回天然有機化合物討論会
Place of Presentation
東京.
Year and Date
20120900
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[Presentation] 不斉分子認識を基盤とする光学活性2,3及び2,5-ジ置換環状ケトン類の効率的供給法(An Efficient Method for Preparation of Optically Active 2,3- and 2,5-Disubstituted Cyclohexanones under Asymmetric Inclusion Complexation).2012
Author(s)
加来裕人,谷由紀子,上原李佳子,西谷亮二,稲井 誠,堀川美津代,角田鉄人
Organizer
Symposium on Molecular Chirality ASIA 2012
Place of Presentation
福岡.
Year and Date
20120500
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