2012 Fiscal Year Final Research Report
New development of studies on the interaction between cell membranes and drugs using sensors
| Project/Area Number |
22590036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
KATSU Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40112156)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Keiichi 群馬大学, 大学院・工学研究科, 助教 (70323334)
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| Project Period (FY) |
2010 – 2012
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| Keywords | センサー / カチオン性ポルフィリン / キサンテン系色素 / 光不活性化 / グラミシジンSアナログ / マストパラン / 抗原虫薬 / 膜透過 |
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| Research Abstract |
We analyzed how cationic porphyrins and xanthene dyes photoinactivated cell membranes using electrochemical sensors, such as ion sensor and oxygen electrode. Furthermore, we applied a K+sensor to cell membrane permeability assay and advanced(1) the development of antimicrobial peptides with low hemolytic activity;(2) the comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells; and(3) the investigation of new substances that enhance the outer membrane of Gram-negative bacteria.
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