2012 Fiscal Year Final Research Report
anti-tumor activity of dinuclear pyrazoratoplatinum complex
| Project/Area Number |
22590045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
SATO Takaji 大阪薬科大学, 薬学部, 講師 (80257899)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Hayato 日本大学, 生産工学部, 助教 (10351488)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 制がん剤 / 白金 / シスプラチン / アポトーシス |
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| Research Abstract |
[{cis-(NH3)2Pt(II)}2 (μ-OH)(μ-pz)](NO3)2 (AMPZ) is more effective in L1210 cell than cisplatin. However, the apoptosis induction potency of AMPZ was lower than that of cisplatin. In L1210, AMPZ led to G2 cell cycle arrest as well as cisplatin. In proteome analysis, annexin A1 was one of the most elevated proteins in the cell treated with cisplatin. Cytocrome C pathway apoptosis induction by cisplatin was markedly decreased in the cisplatin resistant cell. However, resistant cell did not alter the apoptosis and cell cycle arrest induced by AMPZ. These results suggest that cytocrome C is related to induction of apoptosis by cisplatin but not AMPZ.
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