2012 Fiscal Year Final Research Report
Functional analysis of MDGA family proteins on corticogenesis.
| Project/Area Number |
22590055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMAMOTO Tohru 北海道大学, 大学院・薬学研究院, 准教授 (10251480)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大脳皮質 / 細胞移動 / 発生分化 / 神経細胞 / 組織構築 |
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| Research Abstract |
MDGA1 encodes a GPI-anchored IgSF molecule containing MAM domain, which we isolated as a gene expressed by a specific subset of spinal and DRG neurons. In mouse cerebral cortex, MDGA1 is selectively expressed by neurons located in the upper layer. To investigate the function of MDGA1 and MDGA2, the other family member of MDGA1, in corticogenesis, we generated the MDGA1 and MDGA2 deficient mice. The migration of MDGA1/2-mutant neurons to the superficial cortical plate was clearly delayed, indicating that MDGA family proteins are involved in radial migration of projection neurons. The results also indicated that MDGA1 was expressed by and required for a subset of upper layer neurons for their proper migration. Theses observations suggested that radial migration of upper layer neurons in the cortical plate might be differentially regulated among cell types.
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Research Products
(33 results)
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[Journal Article] Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Mol2011
Author(s)
Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T
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Journal Title
Neurodegener
Volume: 6
Pages: 76
Peer Reviewed
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[Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain2010
Author(s)
Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T
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Journal Title
Mol. Neurodegener
Volume: 5
Pages: 35
Peer Reviewed
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