2012 Fiscal Year Final Research Report
Regulation of cell division by tyrosine phosphorylation signaling and its role in cancer development
| Project/Area Number |
22590056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University (2012)
Chiba University (2010-2011) |
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Principal Investigator |
NAKAYAMA Yuji 京都薬科大学, 薬学部, 教授 (10280918)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUMOTO Yasunori 千葉大学, 大学院・薬学研究院, 助教 (10447310)
YAMAGUCHI Naoto 千葉大学, 大学院・薬学研究院, 教授 (00166620)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞分裂 / チロシンリン酸化 / Src チロシンキナーゼ |
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| Research Abstract |
Cell division is tightly regulated in order to prevent cancers, cancer progression and cell death. In this study, we showed that tyrosine phosphorylation signaling by Src-family tyrosine kinases is important for regulation of mitotic spindle formation. In addition, cytokinesis fails upon an increase in Src activity, resulting in generation of binucleated cells.
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