2012 Fiscal Year Final Research Report
Roles of prostaglandin E on the growth and bone metastasis of cancer.
| Project/Area Number |
22590058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MIYAURA Chisato 東京農工大学, 大学院・工学研究院, 教授 (20138382)
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| Co-Investigator(Kenkyū-buntansha) |
INADA Masaki 東京農工大学, 大学院・工学研究院, 准教授 (80401454)
HIRATA Michiko 東京農工大学, 大学院・工学研究院, 講師 (40544060)
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| Project Period (FY) |
2010 – 2012
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| Keywords | プロスタグランジンE / がんの骨転移 / 固形腫瘍 / がん |
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| Research Abstract |
This proposal investigated roles of prostaglandin E (PGE) on the growth, angiogenesis, and bone lose associated with bone metastasis of cancer. In the mouse models of tumor growth and bone metastasis, PGE produced by host cells is essential and EP4 antagonist suppresses the growth and metastasis of cancer in vitro and in vivo.
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