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2012 Fiscal Year Final Research Report

Investigation of host defense mechanisms by sensory nerve transmitter CGRP

Research Project

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Project/Area Number 22590062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

TSUJIKAWA Kazutake  大阪大学, 薬学研究科, 教授 (10207376)

Project Period (FY) 2010 – 2012
KeywordsCGRP / Th 細胞 / 神経系 / 環境因子 / 化学物質
Research Abstract

Calcitonin gene-related peptide (CGRP) suppressed Th1 differentiation and induced Th2, Th9, and Th17 differentiation via activation of the cAMP/protein kinase A pathway and inactivation of GSK-3β leading to nuclear localization of NFATc2. In CGRP receptor-deficient mice, airway inflammation and experimental autoimmune encephalomyelitis were suppressed. Moreover, we found that airway and skin inflammation were promoted by increased production and release of CGRP from mice exposed by chemicals in neonatal.

  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] The Regulatory Mechanisms of Calcitonin Gene-related Peptide (CGRP) in Skin Inflammation2012

    • Author(s)
      Mikami N, Fukada S, Yamamoto H, Tsujikawa K.Yakugaku Zasshi
    • Volume
      132(11)
    • Pages
      1211-5
    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23123709

    • Peer Reviewed
  • [Journal Article] Neuronal Derivative Mediators that Regulate Cutaneous Inflammations2012

    • Author(s)
      Mikami N, Fukada S, Tsujikawa K
    • Journal Title

      Critical Rev. Immunol

      Volume: 32(4) Pages: 307-20

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/23237507

    • Peer Reviewed
  • [Journal Article] Calcitonin gene-related peptide enhances experimental autoimmune encephalomyelitis by promoting Th17 cell functions2012

    • Author(s)
      Mikami N, Watanabe K,Hashimoto N, Miyagi Y, Sueda K, Fukada SI, Yamamoto H, Tsujikawa K
    • Journal Title

      Int Immunol

      Volume: 24(11) Pages: 681-91

    • DOI

      doi:10.1093/intimm/dxs075

    • Peer Reviewed
  • [Journal Article] Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis2012

    • Author(s)
      Jusek G, Reim D, Tsujikawa K, Holzmann B
    • Journal Title

      Immunobiology

      Volume: 217(8) Pages: 761-7

    • DOI

      doi:10.1016/j.imbio.2012.04.009

    • Peer Reviewed
  • [Journal Article] Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome2012

    • Author(s)
      Guo TZ, Wei T, Shi X, Li WW, Hou S, Wang L, Tsujikawa K, Rice KC, Cheng K, Clark DJ, Kingery WS
    • Journal Title

      Mol Pain

      Volume: 28;8 Pages: 85-99

    • DOI

      doi:10.1186/1744-8069-8-85.

    • Peer Reviewed
  • [Journal Article] 皮膚炎と神経ペプチド CGRP.2012

    • Author(s)
      三上統久,辻川和丈
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57 Pages: 450-456

  • [Journal Article] Suppression of ovalbumin-induced allergic diarrhea by diminished intestinal peristalsis in RAMP1-deficient mice2011

    • Author(s)
      Yoshikawa R, Mikami N, Otani I, Kishimoto T, Nishioka S, Hashimoto N, Miyagi Y, Takuma Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 410 Pages: 389-393

    • DOI

      doi:10.1016/j.bbrc.2011.05.141

    • Peer Reviewed
  • [Journal Article] Calcitonin Gene-Related Peptide is an Important Regulator of Cutaneous Immunity: Effect on Dendritic Cell and T Cell Functions2011

    • Author(s)
      Mikami N, Matsushita H, Kato T, Kawasaki R, Sawazaki T, Kishimoto T, Ogitani Y, Watanabe K, Miyagi Y, Sueda K, Fukada S, Yamamoto H, Tsujikawa K
    • Journal Title

      J. Immunol.

      Volume: 186 Pages: 6886-93

    • DOI

      doi:10.4049/jimmunol.1100028

    • Peer Reviewed
  • [Journal Article] 神経ペプチド CGRP による皮膚過敏症の増強2011

    • Author(s)
      三上統久,辻川和丈
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 736-741

  • [Presentation] 知覚神経ペプチド CGRP はマクロファージによる脂肪炎症を制御する2013

    • Author(s)
      村上聡、吉村一樹、三上統久、末田佳織、上田裕子、深田宗一朗、山元 弘、辻川和丈
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-30
  • [Presentation] The regulatory mechanisms of CGRP on IL-12 and IL-10 expression from dendritic cells in DTH models2012

    • Author(s)
      末田佳織、三上統久、深田宗一朗、山元弘、辻川和
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-12-05
  • [Presentation] CGRP and cyclic AMP/PKA pathway promote IL-9 production in Th9 cells2012

    • Author(s)
      三上統久、宮城弥生、深田総一朗、山元弘、辻川 和 丈
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2012-12-05
  • [Presentation] 神経ペプチド CGRP による皮膚免疫制御2012

    • Author(s)
      三上統久、深田総一朗、山元弘、辻川和丈
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2012-07-19
  • [Presentation] 神経ペプチドCGRP の皮膚免疫制御作用2012

    • Author(s)
      三上統久、深田総一朗、山元弘、辻川和丈
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道大学
    • Year and Date
      2012-03-28
  • [Presentation] 脂肪組織における CGRP の炎症制御作用2011

    • Author(s)
      宅間祐太郎, 西岡諭史, 吉村一樹, 鄭洋, 深田宗一朗, 山元弘, 辻川和丈
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-29
  • [Presentation] 神経ペプチド CGRP の cAMP/PKA 経路を介したTh17 細胞分化促進作用2011

    • Author(s)
      三上統久、 渡邉佳子、橋本なぎさ、 深田宗一朗、山元弘、辻川和丈
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
  • [Presentation] The promoting effect of CGRP in Th9 differentiation2011

    • Author(s)
      宮城弥生、三上統久、末田佳織、深田総一朗、山元弘、辻川和丈
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
  • [Presentation] 神経ぺプチドCGRPによる樹状細胞の制御解析2011

    • Author(s)
      末田佳織、三上統久、宮城弥生、深田宗一朗、山元弘、辻川和丈
    • Organizer
      第61回日本薬学会近畿支部
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2011-10-22
  • [Presentation] RAMP1 欠損マウスにおける肥満化の解析2011

    • Author(s)
      宅間祐太郎,西岡諭史 吉村一樹, 鄭洋, 深田宗一朗, 山元弘, 辻川和
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      西岡諭史 吉村一樹, 鄭洋, 深田宗一朗, 山元弘, 辻川和
    • Year and Date
      2011-09-24
  • [Presentation] Calcitonin gene-related peptide promotes Th17 cell differentiation and enhances experimental autoimmune encephalomyelitis2011

    • Author(s)
      Norihisa Mikami, Keiko Watanabe, Nagisa Hashimoto, So-ichiro, Fukada, Kazutake Tsujikawa, Hiroshi Yamamoto
    • Organizer
      7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-06-04
  • [Presentation] 神経ペプチド CGRP のヘルパーT 細胞に対する作用2010

    • Author(s)
      三上統久,深田宗一朗,山元 弘,辻川和丈
    • Organizer
      第20回 Kyoto T Cell Conference
    • Place of Presentation
      京都大学
    • Year and Date
      2010-06-05
  • [Presentation] 神経ペプチド CGRP による皮膚炎症制御機構の解析2010

    • Author(s)
      三上統久、深田宗一朗、辻川和丈、山元 弘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ
    • Year and Date
      2010-03-30
  • [Presentation] カルシトニン遺伝子関連ペプチドによる cAMP/PKA 経路を介した免疫応答制御2010

    • Author(s)
      宮城弥生、吉川倫太郎、三上統久、渡辺桂子、西岡諭史、橋本なぎさ、山田和弘、深田宗一朗、辻川和丈、山元 弘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山桃太郎アリーナ
    • Year and Date
      2010-03-30
  • [Remarks] ホームページ

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b008/info.html

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Published: 2014-08-29  

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