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2012 Fiscal Year Final Research Report

Molecular cellular biology of the cell cycle progression under inhibition of Kinesin Spindle Protein

Research Project

  • PDF
Project/Area Number 22590067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

SAWADA Junichi  静岡県立大学, 大学院・薬学研究院, 准教授 (70381738)

Project Period (FY) 2010 – 2012
Keywords細胞生物学 / 薬理学 / ケミカルバイオロジー / 細胞周期 / がん
Research Abstract

Many targeted drugs with anti-cancer activity are being developed in academic institutes and pharmaceutical companies. Compounds with specific inhibition activity against a mitotic kinesin KSP are categorized in important candidates of such drugs. In this study, we have found a mitotic molecular event of microtubules whose dynamics were disorganized under treatment of the kinesin inhibitor, and shed light on the molecular mechanisms. From the results of these molecular cellular biological studies, we also demonstrated that the kinesin inhibitor prevent tissue culture cells from proliferating synergistically with anti-cancer drug Paclitaxel. Taken together, our results can facilitate understanding how inhibitors against the kinesin work on cancer cell proliferation, and contribute to planning new anti-cancer strategies using drugs.

  • Research Products

    (11 results)

All 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] "Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors"2011

    • Author(s)
      Takeuchi T, Oishi S, Watanabe T, Ohno H, Sawada J, Matsuno K,Asai A, Asada N, Kitaura K, Fujii N.
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 54巻 Pages: 4839-4846

    • DOI

      DOI:10.1021/jm200448n

    • Peer Reviewed
  • [Presentation] A possible effect of nonsteroidal anti-inflammatory drug sulindac on mitotic regulation by aurora kinases2012

    • Author(s)
      澤田潤一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
  • [Presentation] 細胞周期を指標とした抗がん剤スクリーニング研究2012

    • Author(s)
      澤田潤一
    • Organizer
      PerkinElmer 75周年記念イベント For the Better Forum 2012
    • Place of Presentation
      東京・六本木
    • Year and Date
      2012-11-15
  • [Presentation] 細胞イメージングを用いた細胞周期阻害化合物の探索2012

    • Author(s)
      澤田潤一
    • Organizer
      第3回スクリーニング学研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-02
  • [Presentation] Sister-chromatid resolution, a possible chemical target molecular event for cancer therapy2011

    • Author(s)
      澤田潤一
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川・横浜
    • Year and Date
      2011-12-16
  • [Presentation] HCAを活用した創薬探索システムの構築 -ぼくはこうやってスクリーニングを立ち上げた2011

    • Author(s)
      澤田潤一
    • Organizer
      第2回HCA共催セミナー「High-Content Analysisの新展開」
    • Place of Presentation
      東京・品川
    • Year and Date
      2011-06-23
  • [Presentation] 非ステロイド系抗炎症剤の癌予防メカニズム研究 -スリンダクの細胞周期リン酸化酵素Aurora-Bに対する影響2011

    • Author(s)
      澤田潤一
    • Organizer
      日本ケミカルバイオロジー学会第7回年会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-08
  • [Presentation] 表現型を指標にしたM期阻害化合物の探索2011

    • Author(s)
      澤田潤一
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京・目黒
    • Year and Date
      2011-05-24
  • [Presentation] KSP/Eg5 facilitates elongation of chromatin-derived microtubules during mitotic spindle formation2010

    • Author(s)
      澤田潤一
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      兵庫・神戸
    • Year and Date
      2010-12-09
  • [Presentation] KSP/Eg5 facilitates elongation of chromatin-derived microtubules during mitotic spindle formation2010

    • Author(s)
      澤田潤一
    • Organizer
      Cold Spring Harbor Laboratory Meeting "The Cell Cycle"
    • Place of Presentation
      米国・ニューヨーク州
    • Year and Date
      2010-05-20
  • [Remarks] 所属研究機関webページ

    • URL

      http://db.u-shizuoka-ken.ac.jp/show/prof240.html

URL: 

Published: 2014-08-29  

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