2012 Fiscal Year Final Research Report
Visualization ofβ3 adrenoceptor signaling for development of ligand screening.
| Project/Area Number |
22590069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | アドレナリン受容体 / 蛍光 / 脂肪滴 |
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| Research Abstract |
β3 adrenergic receptor acts for transmission ofadrenergic signaling on the cell surface of adipocytes activating hydrolysis of neutral lipids stored in the cells. In this study, I tried visualization of signaling mediated by β3 adrenoceptor. For this purpose, β3 adrenergic receptor, βarrestin2 and perilipin were fused withfluorescent proteins and expressed in mammalian cells. Distributions of fluorescence of these proteins were observed with microscopes.
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Research Products
(6 results)
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[Journal Article] Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution.2010
Author(s)
Kojima N., Morioka T., Urabe D., Yano M, Suga Y., Maezaki N., Ohashi-Kobayashi A., Fujimoto Y., Maeda M., Yamori T., Yoshimitsu T. and Tanaka T.
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Journal Title
Bioorg. Med. Chem.
Volume: 18 (24)
Pages: 8630-8641
DOI
Peer Reviewed
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