2012 Fiscal Year Final Research Report
Novel function of cardiolipin in the gonad development ofC. Elegans
| Project/Area Number |
22590072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Taro 北里大学, 薬学部, 助教 (10383655)
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| Project Period (FY) |
2010 – 2012
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| Keywords | カルジオリピン / ミトコンドリア / 脂質 / 線虫 / 生殖細胞 |
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| Research Abstract |
Cardiolipin (CL) is an acidic phospholipid specifically localized in mitochondrial inner membrane. By interacting with various mitochondrial proteins, CL contributes to the maintenance of the structure and function of those mitochondrial proteins. In this study, by analyzing deletion mutants of a CL synthase gene (crls-1) in C. elegans, we demonstrated that CL depletion selectively caused abnormal mitochondrial function and morphology in germ cells but not in somatic cells. This is the first study to show varying susceptibilities among different cell types to CL depletion in vivo.
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