2012 Fiscal Year Final Research Report
Bronchial epithelial cells as the targets of the therapy for refractory asthma of elderly patients.
| Project/Area Number |
22590075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Naoyuki 東京大学, 助教 (20337447)
TATE Naoko 帝京大学, 薬学部, 教授 (00201955)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アレルギー・ぜんそく / 老化 / 薬学 / 細胞・組織 |
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| Research Abstract |
Inhaled- steroid bring the great advance in the therapy of athma. However, as for an elderly's asthma, the impairment of a respiratory-epithelium cells and its structural change break out refractory cases from a severe airway inflammation and remodeling. So, in this study, we analyzed the therapeutic potential of the novel curcumin derivative and the endogenous ligand of the alpha7 subunit of nicotinic acetylcholine receptors, and clarified its effectiveness in airway inflammation and remodeling.
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[Journal Article] The role of CCR7 inallergic airway inflammation induced by house dust mite exposure2012
Author(s)
Kawakami, M., O. Narumoto, Y. Matsuo, K. Horiguchi, S. Horiguchi, N. Yamashita, M. Sakaguchi, M. Lipp, T. Nagase, and N.Yamashita
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Journal Title
Cellular immunology
Volume: 275
Pages: 24-32
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[Journal Article] Suppressive effects of a pyrazolederivative of curcumin on airway inflammation and remodeling2012
Author(s)
Narumoto, O., Y. Matsuo, M. Sakaguchi, S. Shoji, N. Yamashita, D. Schubert, K. Abe, K. Horiguchi, T. Nagase, and N. Yamashita
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Journal Title
Experimental and molecular pathology
Volume: 93
Pages: 18-25
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[Journal Article] Growth inhibition and apoptosis by an active component of OK-432, a streptococcal agent, via Toll-like receptor 4 in human head and neck cancer cell lines2012
Author(s)
Tano, T., M. Okamoto, S. Kan, K. Nakashiro, S. Shimodaira, N. Yamashita, Y. Kawakami, and H. Hamakawa
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Journal Title
Oral oncology
Volume: 48
Pages: 678-685
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[Journal Article] Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allostericalpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions2010
Author(s)
Narumoto, O., K. Horiguchi, S. Horiguchi, Y. Moriwaki, H. Takano-Ohmuro, S. Shoji, H. Misawa, N. Yamashita, T. Nagase, K. Kawashima and N Yamashita
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Journal Title
Biochemical and biophysical research communications
Volume: 398
Pages: 713-718
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