2012 Fiscal Year Final Research Report
Elucidation of the epigenetic regulation on the stress resistance
| Project/Area Number |
22590086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
TAKEDA Hiroshi 国際医療福祉大学, 薬学部, 教授 (70206986)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Minoru 国際医療福祉大学, 薬学部, 准教授 (70297307)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ストレス / ストレス抵抗性 / 5-HT_1A 受容体 / トリコスタチン A / エピジェネティクス / ヒストン脱アセチル化酵素 / ストレス性精神疾患 |
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| Research Abstract |
We found that acetylated histone H3 was increased in the hippocampus of mice that had developed resistance to emotional stress by pretreatment with 5 -HT_1Areceptor agonist 24 h before testing.Interestingly, the histone deacetylase inhibitor trichostatin A also protected against the emotional changes induced by acute restraint stress, as well as histone H3 acetylation. The present findings suggest that the epigenetic mechanisms of gene regulation may play an important role in the development of emotional resistance to stress stimuli.
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