2012 Fiscal Year Final Research Report
Regulation of hippocampal neurogenesis by the amygdala
| Project/Area Number |
22590089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
ABE Kazuho 武蔵野大学, 薬学研究所, 教授 (60202660)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 海馬 / 神経新生 / 扁桃体 |
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| Research Abstract |
The present study investigated whether the amygdala plays a role in regulation of neurogenesis in the hippocampus. Transection of the fimbria-fornix in the rat resulted in an increase of the number of neural stem cells (bromodeoxyuridine-positive cells) in the dentate gyrus. Lesion of the amygdala in the rat resulted in a decrease of the number of neural stem cells in the dentate gyrus. These results suggest that hippocampal neurogenesis is regulated by the amygdala.
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