2012 Fiscal Year Final Research Report
A study on the roles of nNOS-SUMO-1 conjugation and NO-nNOS machinery in PTZ-induced convulsive seizure
| Project/Area Number |
22590095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Kouichi 徳島文理大学, 薬学部, 教授 (30291149)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Takayuki 徳島文理大学, 薬学部, 准教授 (10397557)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経薬理学 / てんかん / 一酸化窒素 (NO) / 一酸化窒素合成酵素 (nNOS) / ペンチ レンテトラゾール (PTZ) / small ubiquitin-related modifier (SUMO) |
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| Research Abstract |
We previously reported that excessive nitric oxide (NO) was generated by neuronal NO synthase (nNOS) which is persistently increased in the generalized epilepsy model of pentylenetetrazole (PTZ)-induced kindling rodents, which is caused by abnormal neuronal activity. In this study, we characterized a novel posttranslational modification in nNOS by small ubiquitin-related modifier (SUMO) which regulates protein stability, activity and localization. In addition, we found that the threshold of PTZ-induced convulsive seizure was defined by the NO levels in various brain regions of mice.
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