2012 Fiscal Year Final Research Report
Roles of intracellular signaling through lysophospholipid receptors in synovial cells in rheumatoid arthritis pathogenesis.
| Project/Area Number |
22590096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
TAMOTO Koichi 徳島文理大学, 香川薬学部, 教授 (50088861)
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| Co-Investigator(Kenkyū-buntansha) |
NOCHI Hiromi 徳島文理大学, 香川薬学部, 准教授 (30183552)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 関節リウマチ / 滑膜細胞 / リゾリン脂質 / リゾホスファチジン酸 / LPA 受容体 |
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| Research Abstract |
In rheumatoid arthritis (RA), inflammatory cells infiltrate into thesynovial tissues and release inflammatory mediators which result in synovitis anddestruction of articular structure. Of these inflammatory mediators, the action mechanismof lysophosphatidic acid (LPA) in RA synoviocytes is still unclear. Furthermore, theacidification of RA synovial fluid has been reported, suggesting the importance of acidiccondition surrounding synovial cells in RA pathogenesis. In this study, we analysedcellular responses in RA synovial cells. Our results suggested that, in addition toinflammatory cytokines, LPA in synovial fluid and acidification of synovial fluid may becritical components in RA pathogenesis.
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