2012 Fiscal Year Final Research Report
A Versatile method for the synthesis of DTPA bearing functionalized side chain toward the application to MRI clinical diagnosis
| Project/Area Number |
22590101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
NEMOTO Hisao 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (30208293)
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| Project Period (FY) |
2010 – 2012
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| Keywords | MRI / 重金属キレート / Stevens転位 / DTPA |
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| Research Abstract |
A versatile method for the synthesis of DTPA bearing functionalized side chain was successfully accomplished. Introduction of only one side chain to DTPA, the key reaction, was succeeded in spite of the five reacting points in DTPA framework. Introduction of functional group at the terminus of the side chain, and connection of several pharmacokintic molecules with the functionalgroup was also succeeded. A parameter for MRI contrast of the target molecule was measured by MRI spectrometer. A compound was injected to mice to observe MRI image.
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Research Products
(30 results)
