2012 Fiscal Year Final Research Report
Study for protective and harmful effects of environmental factors on emotional system and its development
| Project/Area Number |
22590118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548)
SOEDA Fumio 熊本大学, 大学院・生命科学研究部, 助教 (10336216)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 環境衛生学 |
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| Research Abstract |
We studied how environmental factors in early life stage affectemotional brain functions by using electrophysiological, neurochemical and behavioralscience techniques. Psychologically stressful environments alter receptor functions tomonoamines and/or amino acids or responsiveness to them. Expression levels of GIRK2 and5-HT1Areceptor were not affected. Short but repeated maternal isolation tended to increaseaggressive behavior. Environmental natural sounds such as sounds of a stream protectedfrom the effects observed at single neuron level of short but repeated maternal isolation.
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