Role of interlukin-1 in the cytotoxicity of intact Mycobacterium tuberculosis against host cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: TAKII Takemasa 名古屋市立大学, 大学院・薬学研究科, 准教授 (80244573)
• Project Period (FY): 2010 – 2012
• Keywords: 微生物 / 感染症学

Research Abstract

This study revealed that reactive oxygen species and reactive nitrogen species from Mycobacterium tuberculosis infected cells partly causes the host cell death, through the production of pro-inflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha from the infected host cell. Experiments using an inhibitor of protein synthesis in eukaryote, indicated that other factors from the infected host cells also contributed to this cytotoxic event.

Research Products

• [Journal Article] 結核ワクチンの新しい展開 (2013)
  • Author(s): 瀧井猛将、林 大介、山本三郎
  • Journal Title: ファルマシア Volume: 49(3) Pages: 206-10
• [Journal Article] Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes. (2013)
  • Author(s): Itoh S, Yamaoka N, Kamoshida G, Takii T, Tsuji T, Hayashi H, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 433(1) Pages: 127-32
  • DOI: doi:10.1016/j.bbrc.2013.02.050.
  • Peer Reviewed
• [Journal Article] Cigarette Smoke Condensate Extracts Induce IL-1-Beta Production from Rheumatoid Arthritis Patient-Derived Synoviocytes, But Not Osteoarthritis Patient-Derived Synoviocytes, Through Aryl Hydrocarbon Receptor-Dependent NF-Kappa-B Activation and Novel NF-Kap (2013)
  • Author(s): Adachi M, Okamoto S, Chujyo S, Arakawa T, Yokoyama M, Yamada K, Hayashi A, Akita K, Takeno M, Itoh S, Takii T, Waguri-Nagaya Y, Otsuka T, Hayakawa K, Miyazawa K, Onozaki K.
  • Journal Title: J Interferon Cytokine Res Volume: (in press)
• [Journal Article] Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages. (2012)
  • Author(s): Yokoyama R, Itoh S, Kamoshida G, Takii T, Fujii S, Tsuji T, Onozaki K.
  • Journal Title: Infect Immun. Volume: 80(8) Pages: 2816-25
  • DOI: doi:10.1128/IAI.00399-12.
  • Peer Reviewed
• [Journal Article] Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. (2012)
  • Author(s): Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K.
  • Journal Title: Antimicrob Agents Chemother. Volume: 56(8) Pages: 4140-5
  • DOI: doi:10.1128/AAC.06445-11
  • Peer Reviewed
• [Journal Article] Staphylococcal superantigen-like protein 10 binds to phosphatidylserine and apoptotic cells. (2012)
  • Author(s): Itoh S, Yokoyama R, Murase C, Takii T, Tsuji T, Onozaki K.
  • Journal Title: Microbiol Immunol Volume: 56(6) Pages: 363-71
  • DOI: doi:10.1111/j.1348-0421.2012.00452.x.
  • Peer Reviewed
• [Journal Article] Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line. (2011)
  • Author(s): Xu J, Itoh Y, Hayashi H, Takii T, Miyazawa K, Onozaki K.
  • Journal Title: Biol Pharm Bull. Volume: 34(11) Pages: 1724-30
  • Peer Reviewed
• [Journal Article] Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guerin. (2011)
  • Author(s): Ozeki Y, Hirayama Y, Takii T, Yamamoto S, Kobayashi K, Matsumoto S.
  • Journal Title: Vaccine Volume: 29(40) Pages: 6881-7
  • DOI: doi:10.1016/j.vaccine.2011.07.051.
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. (2011)
  • Author(s): Horita Y, Takii T, Kuroishi R, Chiba T, Ogawa K, Kremer L, Sato Y, Lee Y, Hasegawa T, Onozaki K.
  • Journal Title: Bioorg Med Chem Lett. Volume: 21(3) Pages: 899-903
  • DOI: doi:10.1016/j.bmcl.2010.12.084.
  • Peer Reviewed
• [Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis: Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice. (2011)
  • Author(s): Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 404(4) Pages: 1088-92
  • DOI: doi:10.1016/j.bbrc.2010.12.118.
  • Peer Reviewed
• [Journal Article] Effectiveness of BCG vaccination to aged mice. (2010)
  • Author(s): Ito T, Takii T, Maruyama M, Hayashi D, Wako T, Asai A, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K.
  • Journal Title: Immun Ageing Volume: 7 Pages: 12
  • DOI: doi:10.1186/1742-4933-7-12.
  • Peer Reviewed
• [Journal Article] Cigarette smoke condensate extracts augment collagen-induced arthritis in mice. (2010)
  • Author(s): Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Takii T, Hayakawa K, Onozaki K.
  • Journal Title: Int Immunopharmacol. Volume: 10(10) Pages: 1194-9
  • DOI: doi:10.1016/j.intimp.2010.06.026.
  • Peer Reviewed
• [Journal Article] Biochemical characteristics among Mycobacterium bovis BCG substrains (2010)
  • Author(s): Hayashi D, Takii T, Mukai T, Makino M, Yasuda E, Horita Y, Yamamoto R, Fujiwara A, Kanai K, Kondo M, Kawarazaki A, Yano I, Yamamoto S, Onozaki K.
  • Journal Title: FEMS Microbiol Lett Volume: 306(2) Pages: 103-9
  • DOI: doi:10.1111/j.1574-6968.2010.01947.x.
  • Peer Reviewed
• [Presentation] BCG Tokyo172 株(I 型・II 型)間における酸化ストレス応答性の差異に関する研究 (2013)
  • Author(s): 宮竹佑治,山本三郎,瀧井猛将.
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 千葉
  • Year and Date: 20130318-20
• [Presentation] 酸性条件下における Mycobacterim aviumの arcA mRNA 発現誘導の解析. (2013)
  • Author(s): 小川翔大,小川賢二,大原直也,後藤義孝,瀧井猛将
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 千葉
  • Year and Date: 20130318-20
• [Presentation] トリ型結核菌 Mycobacterium avium のアミノ酸代謝とアンモニア産生に関する研究 (2013)
  • Author(s): 花村菜月,堀田康弘,伊藤佐生智,小川賢二,八木哲也,西森敬, 大原直也, 藤原永年,前田伸司,山崎利雄,瀧井猛将.
  • Organizer: 第88回日本結核病学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2013-03-27
• [Presentation] トリ型結核菌 Mycobacterium avium の増殖とアンモニア産生に関する研究 (2012)
  • Author(s): 花村菜月,瀧井猛将,宮田江里香,筑比地慧,伊藤佐生智,山本龍二,堀田康弘,小川賢二,八木哲也,西森敬,大原直也,藤原永年,前田伸司,山崎利雄,後藤義孝,小野嵜菊夫.
  • Organizer: フォーラム 2012 衛生薬学・環境トキシコロジーシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20121026-27
• [Presentation] 小川翔大,瀧井猛将,伊藤佐生智,非結核性抗酸菌 Mycobacterium avium のpH 環境変化における arcA 遺 伝子発現の解析. (2012)
  • Author(s): 小川翔大,瀧井猛将,伊藤佐生智,山本龍二,堀田康弘,花村菜月,宮田江里香,小川賢二, 八木哲也, 大原直也, 後藤義孝,藤原永年,前田伸司,西森敬,山崎利雄,小野嵜菊夫
  • Organizer: 第24回微生物シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20120903-04
• [Presentation] Mycobacterium avium 亜種 (avium ・hominissuis)間での酸性環境下における菌体外 pH 上昇に関与するアンモニア産生経路の研究 (2012)
  • Author(s): 花村菜月,堀田康弘,小川賢二,八木哲也,西森敬,大原直也,藤原永年,前田伸司,山崎利雄,伊藤佐生智,瀧井猛将.
  • Organizer: 第87回結核病学会
  • Place of Presentation: 広島
  • Year and Date: 20120510-11
• [Presentation] 自然加齢マウスを用いた BCG ワクチンの有効性とブースト効果に関する研究. (2012)
  • Author(s): 谷口恵一,林大介,伊藤佐生智,矢野郁也,山本三郎,瀧井猛将
  • Organizer: 第87回結核病学会
  • Place of Presentation: 広島
  • Year and Date: 20120510-11
• [Presentation] 抗結核作用を示すジチオカルバメート糖誘導体 OCT313 の動態解析 (2012)
  • Author(s): 長谷川倫宏,堀田康弘,伊藤佐生智,瀧井猛将.
  • Organizer: 第87回 日本結核病学会
  • Place of Presentation: 広島
  • Year and Date: 20120510-11
• [Presentation] BCG 亜株(Tokyo172,connaught)間での抗原提示能の差異に関する研究 (2012)
  • Author(s): 宮竹佑治, 瀧井猛将,谷口恵一,林大介,伊藤佐生智,藤原永年,矢野郁也,山本三郎,小野嵜菊夫.
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会 2012
  • Place of Presentation: 岐阜
  • Year and Date: 2012-11-18
• [Presentation] Mycobacterium avium subsp. hominissuis特異的な菌体 外 pH 上昇に関する研究. (2012)
  • Author(s): 小川翔大,瀧井猛将,山本龍二,堀田康弘,花村菜月,小川賢二,八木哲也,西森敬,大原直 也,後藤義孝,藤原永年,前田伸司,伊藤佐生智,小野嵜菊夫.
  • Organizer: 日本薬学会 第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] 抗結核作用を示すジチオカルバメート糖誘導体の pharmacokinetics に関する研究. (2012)
  • Author(s): 長谷川倫宏,瀧井猛将,堀田康弘,筑比地慧,千葉拓,小野嵜菊夫.
  • Organizer: 日本薬学会 第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] BCG ワクチン接種自然加齢マウスにおけるメモリー細胞と Th1 応答の解析. (2012)
  • Author(s): 谷口恵一, 瀧井猛将,宮竹佑治,林大介,伊藤佐生智,矢野郁也,山本三郎,丸山光生,小野嵜 菊夫.
  • Organizer: 日本薬学会 第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] Immunological and biochemical properties of Mycobacterium bovis BCG sub-strainsUS-JAPAN cooperative medical science program (2011)
  • Author(s): Takemasa Takii, Keiichi Taniguchi, Saki Suda, Daisuke Hayashi, Ikuya Yano, Saburo Yamamoto, Kikuo Onozaki.
  • Organizer: 46th tuberculosis and leprosy resarch conference
  • Place of Presentation: Saitama, Japan
  • Year and Date: 20111207-09
• [Presentation] The duration of efficacy of BCG vaccination in murine TB model.BCG の免疫持続に関する研究 (2011)
  • Author(s): 谷口恵一,瀧井猛将,林大介,伊藤佐生智,矢野郁也,山本三郎,丸山光生,小野嵜菊夫.
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 20111127-29
• [Presentation] 結核ワクチン株 Mycobacterium bovis BCG Tokyo-172 I, II 型における酸化ストレスの影響. (2011)
  • Author(s): 谷口恵一,須田早紀,林大介,山本三郎,伊藤佐生智,瀧井猛将,小野嵜菊夫.
  • Organizer: フォーラム 2011 衛生薬学・環境トキシコロジー
  • Place of Presentation: 金沢
  • Year and Date: 20111027-28
• [Presentation] ジチオカルバメ-ト糖誘導体の抗結核作用に関する研究 (2011)
  • Author(s): 長谷川倫宏,瀧井猛将,堀田康弘,千葉拓,森雅美,Angala Shiva ,Chatterjee Delphi,Dean Crick,小野嵜菊夫.
  • Organizer: 第23回微生物シンポジウム
  • Place of Presentation: 千葉
  • Year and Date: 20110903-04
• [Presentation] BCG 亜株の抗原提示能の差異に関する研究. (2011)
  • Author(s): 谷口恵一,林大介,伊藤佐生智,矢野郁也,山本三郎,瀧井猛将.
  • Organizer: 第86回結核病学会
  • Place of Presentation: 東京
  • Year and Date: 20110602-03
• [Presentation] Production of ammonia by Mycobacterium avium in acidic condition. (2011)
  • Author(s): Shouta Ogawa, Takemasa Takii, Ryuji Yamamoto, Yasuhiro Horita, Natsuki Hanamura, Kenji Ogawa, Tetsuya Yagi, Naoya Ohara, Yoshitaka Goto, Nagatoshi Fujiwara, Shinji Maeda, Kikuo Onozaki.
  • Organizer: The International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌
  • Year and Date: 2011-09-10
• [Presentation] ジチオカルバメート誘導体の抗結核作用の機序についての検討. (2011)
  • Author(s): 堀田康弘, 瀧井猛将,千葉拓,藤原永年,小川賢二,黒石隆司, 稲垣衣美,小野嵜菊夫.
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] Mycobacterium bovis BCG の免疫持続に関する研究. (2011)
  • Author(s): 谷口恵一, 瀧井猛将,林大介,丸山光生,小野嵜菊夫.
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 2-acetamide-2-deoxy-β-D-glucopyranosyl N,N-dimethyldithiocarbamate(OCT313) の抗結核作用についての検討. (2011)
  • Author(s): 長谷川倫宏,瀧井猛将,堀田康弘,千葉拓,黒石隆司,小野嵜菊夫.
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] トリ型結核菌亜種のアンモニア産生における Arginine deiminase の関与. (2010)
  • Author(s): 山本龍二,瀧井猛将,堀田康弘,小川賢ニ,小野嵜菊夫.
  • Organizer: 第9回 次世代を担う若手ファーマ・バイオフォーラム 2010
  • Place of Presentation: 京都
  • Year and Date: 20101002-03
• [Presentation] BCG 亜株の抗原提示能の差異および BCG ワクチンの有効性に関する研究第22回微生物シンポジウム (2010)
  • Author(s): 谷口恵一, 瀧井猛将, 林大介, 矢野郁也,山本三郎,丸山光生,小野嵜菊夫.
  • Organizer: 第22回微生物シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20100903-04
• [Presentation] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains. (2010)
  • Author(s): D. Hayashi, T. Takii, N. Fujiwara, Y. Fujita, I. Yano, S. Yamamoto, M. Kondo, E. Yasuda, E. Inagaki, K. Kanai, A. Fujiwara, Y. Horita, K. Taniguchi, T. Chiba, K. Onozaki.
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20100822-27
• [Presentation] 抗酒薬ジスルフィラムの抗結核薬への応用 (2010)
  • Author(s): 瀧井猛将
  • Organizer: 第9回バイオテクノロジー国際会議
  • Place of Presentation: 東京
  • Year and Date: 2010-06-30
• [Presentation] 抗酒癖薬ジスルフィラムの結核菌特異的な作用に関する研究 (2010)
  • Author(s): 堀田康弘,小川賢二,瀧井猛将.
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-21
• [Presentation] トリ型結核菌亜種のアンモニア産生における arginine deiminase の関与. (2010)
  • Author(s): 山本龍二,小川賢二,堀田康弘,瀧井猛将
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-21
• [Presentation] 推定病原性因子のサイトカイン誘導能についての研究 (2010)
  • Author(s): 谷口恵一,市川和哉,小川賢二,堀田康弘,瀧井猛将.
  • Organizer: 第85回日本結核病学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-21
• [Book] 薬学用語辞典日本薬学会編 (2012)
  • Author(s): 瀧井猛将
  • Publisher: 東京化学同人
• [Book] The potential therapeutic usage of dithiocarbamate sugar derivatives for multi-drug resistant tuberculosis.Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance, Pere-Joan Cardona (Ed.) (2012)
  • Author(s): Takemasa Takii, Yasuhiro Horita, Ryuji Kuroishi, Taku Chiba, Mashami Mori, Tomohiro Hasegawa, Tastuya Ito, Tatsuaki Tagami, Tetsuya Ozeki, Saotomo Itoh and Kikuo Onozaki
  • Total Pages: 263-272
  • Publisher: InTech
• [Book] BCG -Vaccine and Adjuvant- Japan Anti-Tuberculosis Association (2011)
  • Author(s): Takemasa Takii, Jun-ichi Maeyama, Saburo Yamamoto
• [Remarks] ホームページ
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/esk/index.html
• [Patent(Industrial Property Rights)] 抗凝固薬及びその用途 (2011)
  • Inventor(s): 伊藤佐生智, 瀧井猛将, 小野嵜菊夫,横山領介,辻勉,鴨志田剛
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Industrial Property Number: 特願 2011-090473
  • Filing Date: 2011-04-14
• [Patent(Industrial Property Rights)] 抗結核薬及びその用途(ジスルフィラム) (2010)
  • Inventor(s): 瀧井猛将,堀田康弘,稲垣衣美,小野嵜菊夫
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Industrial Property Number: PCT/2010/050665, 公開:WO2010/087260
  • Filing Date: 2010-01-21