2012 Fiscal Year Final Research Report
Effect of nano-sized zinc oxide and titanium oxide on autoimmune diseases and its mechanisms
Project/Area Number |
22590125
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
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Research Institution | Kobe Pharmaceutical University |
Principal Investigator |
YOSHINO Shin 神戸薬科大学, 薬学部, 教授 (00260729)
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Project Period (FY) |
2010 – 2012
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Keywords | ナノ粒子 / 酸化亜鉛 / 酸化チタン / 自己免疫 / サイトカイン |
Research Abstract |
The effect of nano-sized zinc oxide and titanium oxide on autoimmune diseases was investigated. Collagen-induced arthritis (CIA) in mice was used as a model of autoimmune diseases and various doses of these nanomaterials were administered. As a result, both nano-sized materials failed to influence CIA. However, the materials appeared to increase the production of Th2 cytokines, suggesting that they might affect Th2-dependent allergic diseases.
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Research Products
(9 results)
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[Journal Article] Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma.2012
Author(s)
Nabe, T., Ikedo, A., Hosokawa, F., Kishima, M., Fujii, M., Mizutani, N., Yoshino, S., Ishihara, K., Akiba, S.,Chaplin, D.D.
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Journal Title
Eur. J. Pharmacol.
Volume: 677
Pages: 154-162
DOI
Peer Reviewed
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[Journal Article] Effect of ultrafine zinc oxide (ZnO) nanoparticles on induction of oral tolerance in mice.2010
Author(s)
Matsumura, M., Takasu, N., Nagata, M., Nakamura, K., Kawai, M., Yoshino, S.
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Journal Title
J. Immunotoxicol.
Volume: 7
Pages: 232-237
DOI
Peer Reviewed
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[Journal Article] Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice.2010
Author(s)
Matsumura, M., Nagata, M., Nakamura,K., Kawai, M., Baba, T., Yamaki, K., Yoshino, S.
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Journal Title
Immunopharmacol. Immunotoxicol.
Volume: 32
Pages: 56-62
DOI
Peer Reviewed
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