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2013 Fiscal Year Final Research Report

Anti-carcinogenic effects of zinc by induction of apoptosis and inhibition of DNA methylation

Research Project

  • PDF
Project/Area Number 22590126
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionHiroshima International University

Principal Investigator

TAKIGUCHI Masufumi  広島国際大学, 薬学部, 教授 (90330753)

Project Period (FY) 2010-10-20 – 2014-03-31
Keywords亜鉛 / 抗がん / エピジェネティクス / DNAメチル化 / カドミウム / アポトーシス
Research Abstract

Zinc (Zn) is an essential metal in humans and rodents. Zn in certain instances can also be anti-carcinogenic. In this study, we clarified that Zn is an inducer of apoptosis, programed tumor cell death. The concentration of Zn in cells determines mode of Zn-induced cell death. In addition, the involvement of metallothionein (MT), is induced by Zn, in the regulation of MMP2, has been implicated in tumor cell invasion, and cell invasion was examined. The result strongly suggests that MT promotes cell invasion by up-regulating MMP2. These results proposed that Zn can have both carcinogenic and anti-carcinogenic effects.

  • Research Products

    (8 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Preventive effects of metallothionein against DNA and lipid metabolic damages in dyslipidemic mice under repeated mild stress2013

    • Author(s)
      Minoru Higashimoto, Naohiro Isoyama, Satoshi Ishibashi, Naoko Ogawa, Masufumi Takiguchi, Shinya Suzuki, Yoshinari Ohnishi, and Masao Sato
    • Journal Title

      The Journal of Medical Investigation

      Volume: 60 Pages: 240-248

    • Peer Reviewed
  • [Presentation] 種・々の重金属が細胞内MMP2活性に与える影響2014

    • Author(s)
      西谷典子
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本大学黒髪キャンパス
    • Year and Date
      2014-03-28
  • [Presentation] カドミウムの長期曝露により形質転換したラット肝(TRL1215)細胞の遺伝子発現変動2013

    • Author(s)
      瀧口益史
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2013-09-13
  • [Presentation] 種々の金属がMMP2活性に与える影響2013

    • Author(s)
      西谷典子
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-30
  • [Presentation] 種々の金属がMMP2活性に与える影響2012

    • Author(s)
      西谷典子
    • Organizer
      第51回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      松江
    • Year and Date
      2012-11-30
  • [Presentation] メタロチオネインとマトリックスメタロプロテアーゼ2発現及び細胞浸潤能の関係2011

    • Author(s)
      瀧口益史
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会2011
    • Place of Presentation
      中電ホール
    • Year and Date
      2011-12-08
  • [Presentation] カドミウム毒性に対するラット系統差に関する研究:亜鉛トランスポーターの関与2011

    • Author(s)
      松田千奈
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松
    • Year and Date
      2011-11-12
  • [Presentation] マトリックスメタロプロテアーゼ2発現及び細胞浸潤能に対するメタロチオネイン2の影響2011

    • Author(s)
      瀧口益史
    • Organizer
      フォーラム2011:衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢エクセルホテル東急
    • Year and Date
      2011-10-27

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Published: 2015-07-16  

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