Establishment of system for supporting formulation in cancer chemotherapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: SHIMADA Miki 東北大学, 病院, 准教授 (10196488)
• Co-Investigator(Kenkyū-buntansha): MANO Nariyasu 東北大学, 病院, 教授 (50323035)
• Project Period (FY): 2010 – 2012
• Keywords: 抗がん剤 / 薬物動態 / 副作用

Research Abstract

We developed the simultaneous analysis for anti-cancer drug and its metabolite about irinotecan and gemcitabine. Then, we analyzed serum concentration of anti-cancer drug and it's metabolite with time in patients obtained the agreement to be part of this study and calculated pharmacokinetic parameters. As observed no adverse effect in this period for all of patients, we would assess changes over time in future.When we preliminary added gemcitabine to medium of pancreas cancer cell lines derived from patients with pancreas cancer to know the correlation between the pharmacokinetic profile and gemcitabine-induced cytotoxicity. These results suggest that enhancement of incorporation of gemcitabine to cells, metabolism of gemcitabine to dFdU, or elimination of dFdU extracellularly.

Research Products

• [Journal Article] DCK is frequently inactivated in acquiredgemcitabine-resistant human cancer cells. Biochem Biophys (2012)
  • Author(s): Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba, Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh K Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, and Akira Horii
  • Journal Title: Res. Commun Volume: 421 Pages: 98-104
  • URL: http://www.journals.elsevier.com/bio chemical-and-biophysical-research-co mmunications/
• [Journal Article] Quantification of intracellular and extracellular prostanoids stimulated by A23187 by liquid chromatography/electrospray ionization tandem mass spectrometry (2011)
  • Author(s): Ayako Furugen, Hiroaki Yamaguchi, Nobuaki Tanaka, Hajime Ito, Kazuaki Miyamori, Asuka Fujikawa, Natsuko Takahashi, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, and Ken Iseki
  • Journal Title: J.Chromatogr. B Volume: 879 Pages: 3378-3385
  • URL: http://www.journals.elsevier.com/jou rnal-of-chromatography-b/
• [Journal Article] Biliary bile acids in birds of the Cotingidae family -(24R,25R)-3α,7α,24-trihydroxy-5β- cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic (2011)
  • Author(s): Lee R. Hagey, Takashi Iida, Shoujiro Ogawa, Yuuki Adachi, Mizuho Une, Kumiko Mushiake, Masamitsu Maekawa,Miki Shimada, Nariyasu Mano, and Alan F. Hofmann
  • Journal Title: acid Steroids Volume: 76 Pages: 1126 -1135
  • URL: http://www.journals.elsevier.com/ste roids/
• [Journal Article] An accurate quantitative LC/ESI-MS/MS method for sirolimus in human whole blood (2011)
  • Author(s): Nariyasu Mano, Mayumi Sato, Marina Nozawa, Yotaro Matsumoto, Masaru Mori, Hiroaki Yamaguchi, Junichi Goto, and Miki Shimada
  • Journal Title: J. Chromatogr. B Volume: 879 Pages: 987-992
  • URL: http://www.journals.elsevier.com/jou rnal-of-chromatography-b/
• [Journal Article] Identification and elimination of ionsuppression in the quantitative analysis of sirolimus in human blood by LC/ESI-MS/MS (2011)
  • Author(s): Nariyasu Mano, Marina Nozawa, Mayumi Sato, Masaru Mori, Hiroaki Yamaguchi, Katsuhiro Kanda, Makoto Nogami, Junichi Goto, Miki Shimada
  • Journal Title: J. Chromatogr. B Volume: 879 Pages: 968-974
  • URL: http://www.journals.elsevier.com/jou rnal-of-chromatography-b/
• [Journal Article] Screening of Antibiotics That Interact with Organic Anion-Transporting Polypeptides 1B1 and 1B3 Using Fluorescent Probes (2011)
  • Author(s): Hiroaki Yamaguchi, Toshiko Takeuchi,Masahiro Okada, Minako Kobayashi, Michiaki Unno, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, and Nariyasu Mano
  • Journal Title: Biol. Pharm. Bull Volume: 34 (3) Pages: 389-395
  • URL: https://www.jstage.jst.go.jp/browse/ bpb
• [Journal Article] Tumor necrosis factor-alpha-nuclear factor-kappa B-signaling enhances St2b2 expression during 12-O- tetradecanoylphorbol-13-acetate-indu ced epidermal hyperplasia (2011)
  • Author(s): Toshihiro Matsuda, Miki Shimada, Akira Sato, Takanori Akase, Koichi Yoshinari, Kiyoshi Nagata, and Yasushi Yamazoe
  • Journal Title: Biol. Pharm. Bull Volume: 34 (2) Pages: 183-190
  • URL: https://www.jstage.jst.go.jp/browse/ bpb
• [Journal Article] Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: Estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1 (2010)
  • Author(s): Hiroaki Yamaguchi, Misa Sugie, Masahiro Okada, Tsuyoshi Mikkaichi, Takafumi Toyohara, Takaaki Abe, Junichi Goto, Takanori Hishinuma, Miki Shimada, and Nariyasu Mano
  • Journal Title: Drug Metab. Pharmacokinet Volume: 25 Pages: 314-317
  • URL: https://www.jstage.jst.go.jp/browse/dmpk
• [Journal Article] 眞野成康:臨床現場に貢献する分析科学 (2010)
  • Author(s): 島田美樹
  • Journal Title: ぶんせき Volume: 10 Pages: 502-505
• [Journal Article] 化学診断並びに薬物療法の適正化に寄与する質量分析法 (2010)
  • Author(s): 眞野成康、島田美樹、後藤順一
  • Journal Title: 臨床化学 Volume: 39 Pages: 70-78
• [Journal Article] メタボローム・プロテオーム解析法 (2010)
  • Author(s): 眞野成康
  • Journal Title: 日本臨床化学会東北支部会誌 Volume: 19巻 Pages: 1-10
• [Presentation] 腎機能の低下した肝細胞癌患者における血中sorafenib濃度の推移 (2013)
  • Author(s): 前嶋隆弘、大川星美、近藤泰輝、久道周彦、松浦正樹、下瀬川徹、島田美樹、眞野成康
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 20130327-30
• [Presentation] 安全で有効な薬物療法を目指した臨床現場での取り組み (2013)
  • Organizer: 薬物代謝・分子毒性学仙台セミナー～基礎研究から創薬・臨床へ～
  • Place of Presentation: 仙台
  • Year and Date: 2013-02-16
• [Presentation] LC/ESI-MS/MSによるSunitinibおよび代謝活性物SU12662の血中濃度測定法の構築 (2012)
  • Author(s): 柳利樹、荒屋世一、前川正充、鈴木裕之、齋藤英郎、荒井陽一、久道周彦、島田美樹、眞野成康
  • Organizer: 第29回日本TDM学会・学術大会
  • Place of Presentation: 神戸
  • Year and Date: 20120616-17
• [Presentation] 膵がんゲムシタビン療法のPK/PGx (2012)
  • Author(s): 鈴木裕之、工藤由起、相馬真志、菊地正史、木皿重樹、松浦正樹、久道周彦、江川新一、海野倫明、島田美樹、眞野成康
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 20120328-31
• [Presentation] 治療薬物モニタリングにおける質量分析法の活用 (2012)
  • Author(s): 島田美樹、眞野成康
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-11-30
• [Presentation] 抗がん剤の血中濃度モニタリング:治療効果と副作用管理 (2012)
  • Author(s): 島田美樹、眞野成康
  • Organizer: 日本医療薬学会第46回公開シンポジウム
  • Place of Presentation: 秋田
  • Year and Date: 2012-07-28
• [Presentation] 抗がん剤の血中濃度モニタリングと副作用管理 (2011)
  • Author(s): 島田美樹、眞野成康
  • Organizer: 日本病院薬剤師会東北ブロック第1回学術大会
  • Place of Presentation: 弘前
  • Year and Date: 20111126-27
• [Presentation] 当院化学療法センターにおける薬剤師の役割 (2011)
  • Author(s): 木皿重樹、我妻恭行、久道周彦、村井ユリ子、島田美樹、眞野成康
  • Organizer: 日本病院薬剤師会東北ブロック第1回学術大会
  • Place of Presentation: 弘前
  • Year and Date: 20111126-27
• [Presentation] HPLCによるイリノテカンおよび代謝物の同時定量法の構築 (2011)
  • Author(s): 鈴木澄子、松浦正樹、赤坂和俊、土屋雅美、木皿重樹、久道周彦、石岡千加史、島田美樹、眞野成康
  • Organizer: 第24回バイオメディカル分析科学シンポジウム
  • Year and Date: 20110831-0902
• [Presentation] 肝細胞癌患者のソラフェニブおよび代謝物の血中モニタリング (2011)
  • Author(s): 大川星美、前嶋隆弘、柳利樹、赤坂和俊、土屋雅美、松浦正樹、久道周彦、近藤泰輝、下瀬川徹、島田美樹、眞野成康
  • Organizer: 第24回バイオメディカル分析科学シンポジウム
  • Year and Date: 20110831-0902
• [Presentation] 培養細胞中のソラフェニブおよび代謝物定量法の構築 (2011)
  • Author(s): 大川星美、鈴木裕之、森大、前川正充、島田美樹、眞野成康
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110328-0331
• [Presentation] HPLCによるゲムシタビンおよび代謝物の血中濃度測定法の構築 (2011)
  • Author(s): 工藤由起、田村淳、前川正充、鈴木裕之、森大、島田美樹、眞野成康
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 20110328-0331
• [Presentation] がん化学療法の副作用管理とその取り組み (2011)
  • Author(s): 島田美樹
  • Organizer: 平成23年度日本薬学会東北支部第10回医療薬学若手研究者セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2011-09-17
• [Presentation] 当院薬剤部の試験研究における分析科学 (2010)
  • Author(s): 島田美樹、眞野成康
  • Organizer: 第23回バイオメディカル分析科学シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 20100721-0723
• [Presentation] 抗がん剤の副作用管理と薬剤部の取り組み (2010)
  • Author(s): 島田美樹
  • Organizer: 第1回東北大学病院がんセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2010-04-15
• [Remarks]
  • URL: http://www.pharm.hosp.tohoku.ac.jp/