2012 Fiscal Year Final Research Report
Preclinical and clinical studies on the usefulness of a newly developed fast dissolving oral film containing dexamethasone
| Project/Area Number |
22590134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu University |
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Principal Investigator |
ITOH Yoshinori 岐阜大学, 大学院・医学系研究科, 教授 (50159927)
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| Project Period (FY) |
2010 – 2012
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| Keywords | デキサメタゾン / 抗がん剤 / 制吐薬 / 口腔内速溶解フィルム / クロスオーバー試験 / 乳癌患者 |
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| Research Abstract |
We developed for the first time a fast dissolving oral film containing 4 mg dexamethasone (DEX) in cooperation with Tsukioka Film Co.Ltd. In rats, pharmacokinetic properties of DEX were very similar to those obtained after oral administration of DEX suspension. Subsequently, the efficacy and usefulness of DEX film were examined in breast cancer patients who underwent chemotherapy. Antiemetic effect was similar between film and tablet. Moreover, patient’s impressionson the oral acceptability in respect of the taste and ease in taking were significantly better for film than for tablet.
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[Journal Article] Development of fast dissolving oral film containing dexamethasone as an antiemetic medication: clinical usefulness2012
Author(s)
Nishigaki M, Kawahara K, Nawa M, Futamura M, Nishimura M, Matsuura K, Kitaichi K, Kawaguchi Y, Tsukioka T, Yoshida K, Itoh Y
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Journal Title
Int J Pharm
Volume: 424
Pages: 12-17
Peer Reviewed
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