2012 Fiscal Year Final Research Report
Assessment of motivational effects of psychiatric agents using rat intracranial self-stimulation behavior
| Project/Area Number |
22590135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳内自己刺激行動 / 強制水泳試験 / 条件づけ場所嗜好行動 / ドーパミン / 意欲 / GBR12909 |
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| Research Abstract |
In the present study, we evaluated the motivational effects of drugs using the novel experimental apparatus in order to accumulate the basal data for elucidating the basal data of neural mechanisms of motivation. The results revealed that dopamine, which was used for neurotransmission in the brain and involved in mood and rewards, played an important role. Furthermore, when the effects in the novel motivational model were compared with that of experimental models related to depressed mood and drug dependence, it was showed the possibility that different neural mechanisms are involved in depression, drug dependence and motivation.
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