2012 Fiscal Year Final Research Report
Application of microdosing technique for therapeutic drug monitoring
| Project/Area Number |
22590137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Mitsuhiro 岐阜薬科大学, 薬学部, 准教授 (30433204)
SAJIKI Hironao 岐阜薬科大学, 薬学部, 教授 (50275096)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロドーズ / 薬物血中濃度モニタリング / LC-MS/MS / MALDI-TOF/TOF / 重水素化内部標準物質 |
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| Research Abstract |
The phase 0 microdose (MD) study appears as a new viable concept in the clinical research of the drug development activity. We synthesized clobazam-d2as the internal standard using a H-D exchange reaction. We developed several analytical methods (LC-MS/MS, LCMS-IT-TOF, MALDI-TOF/TOF) using clobazam-d2for the MD study. MD technique may be applied to pharmacokinetic parameter prediction in the therapeutic drug monitoring.
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