2012 Fiscal Year Final Research Report
Inhibitory effects of losartan on arachidonic acid metabolism via cytochrome P450(CYP) enzymes
| Project/Area Number |
22590141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
TODA Takaki 北海道薬科大学, 薬学部, 教授 (00254706)
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| Co-Investigator(Kenkyū-buntansha) |
INOTSUME Nobuo 北海道薬科大学, 薬学部, 教授 (10191892)
HAYAKAWA Toru 北海道薬科大学, 薬学部, 教授 (50337044)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬物動態 / 代謝学 |
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| Research Abstract |
It was shown that losartan, a drug of the treatment for hypertension, decrease the production of epoxyeicosatrienoic acids (EETs) from arachidonic acid by inhibiting some cytochrome P450 (CYP)s. This inhibitory effect was also found in telmisartan, which is the similar anti-hypertensive as losartan. EETs have cardioprotective effects. Therefore, it was suggested that the decrease of EETs production would be related tothe cardiovascular side effects such as arrhythmia of these drugs.
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[Presentation] Different inhibitory effects of angiotensin II receptor blockers on cytochrome P4502C9 dependent formation of epoxyeicosatrienoic acids from arachidonic acid2012
Author(s)
Toda T, Senda A, Riu Y, Fujioka K, Hosokawa A, Yoshimura K, Hayakawa T, Inotsume N, Ask B, Rane A,Eliasson E
Organizer
FIP2012
Place of Presentation
アムステルダム(オランダ)
Year and Date
20121005-06
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