2014 Fiscal Year Final Research Report
Method for predicting clinical pharmacokinetic profiles after oral administration
| Project/Area Number |
22590153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 薬物速度論 / モデリング / シミュレーション / 薬物動態 / 予測 |
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| Outline of Final Research Achievements |
The objective of this study was to develop a modeling and simulation strategy for evaluation of drug absorption profile and for prediction of drug concentration-time curves in human after oral administration. We focused on Tmax and Cmax as easily available pharmacokinetic parameters in animals and human during drug development process, and prediction strategy was constructed by the method of convolution with a use of numerical Laplace transform algorithm. Based on the pharmacokinetic parameters for many drugs in animals and human obtained from literatures, we examined the validity of the prediction strategy and evaluated the predictability. It was suggested that the predictability of the time course profile is dependent on the predictability of Cmax.
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| Free Research Field |
医療薬学
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