2012 Fiscal Year Final Research Report
Development of novel transdermal delivery formulation of incretin using biodegradable microneedle arrays
| Project/Area Number |
22590155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATSUMI Hidemasa 京都薬科大学, 薬学部, 助教 (30434666)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロニードル / 経皮吸収 / インクレチン / 吸収改善 |
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| Research Abstract |
The purpose of this study was to evaluate the characteristics of exendin-4 tip-loaded microneedle arrays and to compare their acute efficacy with subcutaneous injections in type 2 diabetic GK/Slc rats. Intraperitoneal glucose tolerance tests after application of exendin-4 tip-loaded microneedle arrays were also compared with those after subcutaneous injection in type 2 diabetic GK/Slc rats. Glucose tolerance was improved and the insulin secretion was enhanced after application of exendin-4 tip-loaded microneedle arrays, and these effects were comparable to those after subcutaneous injection of exendin-4. Similar plasma concentration profiles were seen after application of exendin-4 tip-loaded microneedle arrays, as was the case with subcutaneous injection in type 2 diabetic GK/Slc rats. These findings indicate that exendin-4 tip-loaded microneedle arrays can be used as an alternative toachieve sufficient delivery of exendin-4 for treatment of type 2 diabetes.
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