Research of the mechanism of anti-visceral fat accumulation in Suncus murinus

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Kanazawa University
• Principal Investigator: YI Shuang-qin 金沢大学, 医学系, 准教授 (70334753)
• Co-Investigator(Kenkyū-buntansha): SHIRAISHI Yoshitake 金沢大学, 医学系, 技術専門員 (70467116) ; OZAKI Noriyuki 金沢大学, 医学系, 教授 (40244371)
• Project Period (FY): 2010 – 2012
• Keywords: 内臓脂肪蓄積 / 肥満 / pancreatic polypeptide / 高脂肪食 / 摂食因子 / 脂肪幹細胞 / Suncus murinus

Research Abstract

According to the result of the research of high-fat diet to Suncus murinus, it was showed the diets or nutrition could not result directly obesity or visceral fat accumulation, and the anti-visceral fat accumulation maybe relate to the fat metabolism in Suncus murinus. The receptor of pancreatic polypeptide, Y4, distributed wildly and expressed highly in the gastrointestinal tract, it implied the distribution was in connection with the phenomenon of obesity-resistance in Suncus murinus. Furthermore, compare to the adipose tissues in whole body, the distribution and the differentiation potency of adipose progenitor cells were lack in the mesenteric tissue of Suncus murinus.

Research Products

• [Journal Article] Gross anatomical study of bilateral megaureters associated with renal pelvis dilatation and a giant urinary bladder: an adult cadaver with a brief review of the literature (2013)
  • Author(s): Terayama H, Yi SQ, Hirai S, Qu N, Naito M, Hatayama N, Kawata S, Itoh M
  • Journal Title: Anat Sci Int Volume: 88 Pages: 171-174
  • DOI: DOI:10.1007/s12565-013-0172-3
  • Peer Reviewed
• [Journal Article] The three most common variations of the left renal vein: a review and meta-analysis (2012)
  • Author(s): Yi SQ, Ueno Y, Naito M, Ozaki N, Itoh M
  • Journal Title: Surg Radiol Anat Volume: 34 Pages: 799-804
  • DOI: DOI:10.1007/s00276-012-0968-1
  • Peer Reviewed
• [Journal Article] 【肝胆膵の外科解剖】 膵頭部の神経解剖 (2011)
  • Author(s): 易 勤,太田哲生,尾崎紀之
  • Journal Title: 胆と膵 Volume: 32 Pages: 1157-1162
• [Journal Article] 【肝胆膵の外科解剖】 膵頭部の神経解剖 (2011)
  • Author(s): 易 勤,太田哲生,尾崎紀之
  • Journal Title: 胆嚢の神経支配 Volume: 32 Pages: 1129-1134
• [Journal Article] Involvement of NGF in the rat model of persistent muscle pain associated with taut band (2011)
  • Author(s): Hayashi K, Ozaki N, Kawakita K, Itoh K, Mizumura K, Furukawa K, Yasui M, Hori K, Yi SQ, Yamaguchi T, Sugiura Y
  • Journal Title: J Pain Volume: 12 Pages: 1059-1068
  • DOI: DOI:10.1016/j.jpain.2011.04.010
  • Peer Reviewed
• [Journal Article] Immunolocalization of the PP family and its receptors in the gastrointestinal tract of house musk shrew (2011)
  • Author(s): Yi SQ, Li J, Yamaguchi T, Hori K, Hayashi K, Itoh M, Ozaki N
  • Journal Title: Suncus murinus. Neuro Endocrinol Lett Volume: 32 Pages: 212-219.
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21552195
  • Peer Reviewed
• [Journal Article] Multiple renal vessels associated with testicular vessels (2011)
  • Author(s): Naito M, Hirai S, Terayama H, Qu N, Yi SQ, Miyaki T
  • Journal Title: Surg Radiol Anat Volume: 33 Pages: 637-639
  • DOI: DOI:10.1007/s00276-011-0793-y
  • Peer Reviewed
• [Journal Article] A left testicular artery arising from a middle mesenteric artery (2011)
  • Author(s): Naito M, Yi SQ, Terayama H, Hirai S, Qu N, Itoh M
  • Journal Title: Clinical Anatomy. Clin Ana Volume: 24 Pages: 266-267
  • DOI: DOI:10.1002/ca.21090
  • Peer Reviewed
• [Journal Article] Immunolocalization of ghrelin in the stomach of Sprague-Dawley rat (2011)
  • Author(s): Li J, Yi SQ, Wang HX, Yi N, Ogawa Y, Ozaki N, Itoh M
  • Journal Title: Anat Histol Embryol Volume: 40 Pages: 95-99
  • DOI: DOI:10.1111/j.1439-0264.2010.01044.x.
  • Peer Reviewed
• [Journal Article] Histological development of human testicular cords from 70 to 90 days of gestation (2010)
  • Author(s): Kurihara M, Qu N, Cho BH, Kitaoka M, Ogawa Y, Yi SQ, Moriyama H, Hannno S, Murakami G
  • Journal Title: Okajimas Folia Anat Jpn Volume: 87 Pages: 103-108
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21174939
  • Peer Reviewed
• [Journal Article] Anomalous bifurcation and island formation of the carotid artery (2010)
  • Author(s): Iimura A, Oguchi T, Yamazaki Y, Matsuo M, Yi SQ, Itoh M, Takahashi T
  • Journal Title: Okajimas Folia Anat Jpn Volume: 86 Pages: 121-128
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20560448
  • Peer Reviewed
• [Journal Article] Distribution of ghrelin cells in stomach and the effect of ghrelin intraperitoneal administration in house musk shrew (Suncus murinus) (2010)
  • Author(s): Li J, Yi SQ, Terayama H, Naito M, Hirai S, Qu N, Wang HX, Yi N, Ozaki N, Itoh M.
  • Journal Title: Neuroendocrinol Lett Volume: 31 Pages: 406-412
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20588248
  • Peer Reviewed
• [Journal Article] Anterior inferior pancreaticoduodenal artery running between the dorsal and ventral pancreas: morphological and embryological viewpoint (2010)
  • Author(s): Yi N, Yi SQ, Wang HX, Ogawa Y, Ohta T, Ozaki N, Itoh M
  • Journal Title: Open Anat J Volume: 2 Pages: 91-97
  • URL: http://www.benthamscience.com/open/toanatj/articles/V002/79TOANATJ.pdf
  • Peer Reviewed
• [Journal Article] 上腹部消化器官の自律神経支配-臨床解剖の視点からの解析 (2010)
  • Author(s): 易 勤
  • Journal Title: 金沢大十全医会誌 Volume: 119 Pages: 2-6
• [Journal Article] Effects of splenectomy on spontaneously chronic pancreatitis in aly/aly mice (2010)
  • Author(s): Wang HX, Yi SQ, Li J, Terayama H, Naito H, Hirai S, Qu N, Yi N, Itoh M
  • Journal Title: Clin Dev Immunol
  • DOI: DOI:10.1155/2010/614890.
  • Peer Reviewed
• [Journal Article] House musk shrew, Suncus murinus: a novel and natural obesity-resistant animal model (2010)
  • Author(s): Yi SQ, Li J, Qu N, Wang HX, Itoh M, Yamaguchi T, Oda S, Ozaki N.
  • Journal Title: Obes Metab Volume: 6 Pages: 22-28
  • Peer Reviewed
• [Journal Article] A unique variation of the pudendal nerve (2010)
  • Author(s): Yi SQ, Itoh M
  • Journal Title: Clin Anat Volume: 23 Pages: 907-908
  • DOI: DOI:10.1002/ca.20925.
  • Peer Reviewed
• [Presentation] 成熟分化脂肪細胞を欠損するスンクス腸間膜には脂肪幹細胞も存在しない. (2012)
  • Author(s): 山本靖彦,易 勤,斎藤英仁,棟居る聖一,尾崎紀之,山本博
  • Organizer: 第56回日本糖尿病学会
  • Place of Presentation: ホテル日航熊本(熊本)
  • Year and Date: 2012-12-16
• [Presentation] スンクスには腸管膜脂肪細胞が存在しない (2012)
  • Author(s): 山本靖彦,易 勤,齋藤英仁,棟居聖一,尾崎紀之,山本博
  • Organizer: 第85回日本生化学学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ(福岡)
  • Year and Date: 2012-12-16
• [Presentation] The direct neural connections between gall bladder and duodenum, the sphincter of Oddi in Suncus murinus (2012)
  • Author(s): Yi SQ, Nakamura T, Shiraishi Y, Yamaguchi T, Hori K, Ozaki N.
  • Organizer: 第1回アジア臨床解剖学会
  • Place of Presentation: Haeundae Centum Hotel (Busan, Korea)
  • Year and Date: 2012-11-04
• [Presentation] Involvements of CRF and NGF in animal models of stress-induced Functional Dyspepsia (2012)
  • Author(s): Kozakai Y, Hayashi K, Yi SQ, Hori K, Yamaguchi T, Ozaki N
  • Organizer: 国際疼痛学会
  • Place of Presentation: Milano Convention Centre (Milan, Italy)
  • Year and Date: 2012-08-31
• [Presentation] P2X3,2/3and ASICs plays a key role in muscle hyperalgesia and intermittent claudication in a new rat model of peripheral arterial disease (2012)
  • Author(s): Hori K, Hayashi K, Sugiura Y, Yi SQ, Yamaguchi T, Ozaki N
  • Organizer: 国際疼痛学会
  • Place of Presentation: Milano Convention Centre (Milan, Italy)
  • Year and Date: 2012-08-31
• [Presentation] 機能性胃腸症モデル動物におけるCRFの関与 (2012)
  • Author(s): 小酒井友,林 功栄,白石昌武,堀 紀代美,中村恒夫,易 勤,山口豪,尾崎紀之
  • Organizer: 第117回日本解剖学会総会
  • Place of Presentation: 山梨大学内(山梨)
  • Year and Date: 2012-03-30
• [Presentation] スンクス膵臓の構造 (2012)
  • Author(s): 易 勤
  • Organizer: 第6回スンクス研究会
  • Place of Presentation: 山梨大学内(山梨)
  • Year and Date: 2012-03-28
• [Presentation] スンクスの精巣及び精路の神経支配におけるホールマウント免疫組織化学的研究 (2011)
  • Author(s): 易 勤,中村恒夫,山口豪,堀紀代美,林功栄,白石昌武,尾崎紀之
  • Organizer: 第71回日本解剖学会中部支部学術集会
  • Place of Presentation: 名古屋大学(愛知県)
  • Year and Date: 2011-10-16
• [Presentation] 筋・筋膜性疼痛症候群モデルラットにおける持続性の筋機械性痛覚過敏には脊髄マイクログリアが関与する (2011)
  • Author(s): 林功栄,易 勤,山口豪,堀紀代美,尾崎紀之.
  • Organizer: 第71回日本解剖学会中部支部学術集会
  • Place of Presentation: 名古屋大学(愛知県)
  • Year and Date: 2011-10-16
• [Presentation] 前下膵十二指腸動脈は背側膵と腹側膵の境界にある--形態形成学的視点から (2011)
  • Author(s): 易 勤,山 口 豪,堀 紀美,伊藤正裕,尾崎紀之
  • Organizer: 第15回臨床解剖研究会
  • Place of Presentation: 東京大学(東京)
  • Year and Date: 2011-09-03
• [Presentation] Whole mount immunohistological observation of the testicular innervation in Suncus murinus (2011)
  • Author(s): Yi SQ, Nakamura T, Shiraishi Y, Yamaguchi T, Hori K, Ozaki N
  • Organizer: 第116回日本解剖学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-03-30
• [Presentation] alyマウスの自然発症慢性膵炎における膵臓摘出術後の影響 (2011)
  • Author(s): 王恒孝, 易 勤, 李 軍, 寺山隼人, 内藤宗和, 平井宗一, 曲寧, 易望美, 伊藤正裕.
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手県民会館(盛岡)
  • Year and Date: 2011-03-30
• [Presentation] スンクスの胃におけるghrelinの分布およびghrelin投与後の影響 (2011)
  • Author(s): 李 軍, 易 勤, 寺山隼人, 内藤宗和, 平井宗一, 曲 寧, 王恒孝, 易望美, 伊藤正裕
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手県民会館(盛岡)
  • Year and Date: 2011-03-30
• [Presentation] whole mount免疫組織学的法を用いてスンクス肝臓神経分布の包括的解析 (2011)
  • Author(s): 易 勤, 中村恒夫, 白石昌武, 山口豪, 尾崎紀之
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手県民会館(盛岡)
  • Year and Date: 2011-03-30
• [Presentation] スンクスの直腸脱について (2010)
  • Author(s): 中村恒一,易 勤,山口豪,堀紀代美,林功栄,白石昌武,尾崎紀之
  • Organizer: 第70回日本解剖学会中部支部学術集会
  • Place of Presentation: じゅうろくプラザ(岐阜)
  • Year and Date: 2010-10-17
• [Presentation] 肝臓内外神経分布の包括的解析. (2010)
  • Author(s): 易 勤,中村恒一,白石昌武,山口豪,堀紀代美,林功栄,尾崎紀之
  • Organizer: 第14回臨床解剖研究会
  • Place of Presentation: ホテル金沢(石川県)
  • Year and Date: 2010-09-11
• [Presentation] 大動脈後性左腎静脈,大動脈周囲性左腎静脈輪と腰静脈との吻合枝 (2010)
  • Author(s): 上野洋資,易 勤,山口豪,宮木孝昌,伊藤正裕,尾崎紀之
  • Organizer: 第14回臨床解剖研究会
  • Place of Presentation: ホテル金沢(石川県)
  • Year and Date: 2010-09-11
• [Presentation] Effects of splenectomy on spontaneously chronic pancreatitis in aly/aly mice (2010)
  • Author(s): Yi SQ, Wang HX, Qu N, Itoh M, Ozaki N
  • Organizer: 第14回国際膵臓学会・第41回日本膵臓学会大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2010-07-13
• [Book] スンクスの生物学 (2011)
  • Author(s): 易 勤,竹内京子
  • Total Pages: 116-124
  • Publisher: 学会出版センター
• [Book] 肝臓と膵臓の組織構造.スンクスの生物学 (2011)
  • Author(s): 易 勤
  • Total Pages: 132-136
  • Publisher: 学会出版センター
• [Book] 消化器系の自律神経 (2011)
  • Author(s): 易 勤
  • Total Pages: 200-203
  • Publisher: スンクスの生物学.学会出版センター
• [Book] 膵臓の内分泌部 (2011)
  • Author(s): 易 勤
  • Total Pages: 211-213
  • Publisher: スンクスの生物学
• [Book] スンクスの直腸脱出の習性 (2011)
  • Author(s): 中村恒夫,易勤,尾崎紀之
  • Total Pages: 307-309
  • Publisher: スンクスの生物学.学会出版センター