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2012 Fiscal Year Final Research Report

Pathology and molecular mechanism of embryonic edema in mice carrying endothelial gene mutations

Research Project

  • PDF
Project/Area Number 22590173
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKobe University

Principal Investigator

HIRASHIMA Masanori  神戸大学, 大学院・医学研究科, 准教授 (40383757)

Co-Investigator(Renkei-kenkyūsha) MORIWAKI Kazumasa  神戸大学, 大学院・医学研究科, グローバルCOE 研究員 (00467656)
DING Guo  神戸大学, 大学院・医学研究科, グローバルCOE 研究員 (00514697)
Project Period (FY) 2010 – 2012
Keywords発生学 / 形態形成学
Research Abstract

We analyzed vascular permeability and development of the heart, blood vessels, and lymphatic vessels in Aspp1-/- and Flt1+/- mice showing embryonic edema. Lymphatic vascular development is defective in Aspp1-/- embryos, whereas vascular permeability is enhanced in Flt1+/- embryos with enhancement ofFlk1 phosphorylation. Transmission electron microscopic analysis reveals an intricateluminal surface and huge vesicle-like structures in Flt1+/- capillary endothelial cells,suggesting a promoted transcellular transport. Our analysis also shows that defectivelymphatic vessels and enhanced vascular permeability cause embryonic lethality of Aspp1-/-;Flt1+/- mice.

  • Research Products

    (7 results)

All 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice2012

    • Author(s)
      Keigo Sano, Osamu Katsuta, Satoshi Shirae, Yoshiaki Kubota, Masatsugu Ema, Toshio Suda, Masatsugu Nakamura and Masanori Hirashima
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420(2) Pages: 422-427

    • DOI

      DOI:10.1016/j.bbrc.2012.03.011

    • Peer Reviewed
  • [Presentation] 血小板はどのようにしてリンパ管網の独自性を守るのか2012

    • Author(s)
      平島正則
    • Organizer
      第36回日本リンパ学会総会「シンポジウム・リンパ管の形成・機能の発現を左右する重要因子
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-06-29
  • [Presentation] Platelets Contribute to the Separation between Blood Vessels and Lymphatic Vessels during Lymphatic Sprouting2011

    • Author(s)
      Guo Ding, Katsue Suzuki Inoue, Osamu Inoue, Masaki Hikida, Tomohiro Kurosaki, Masanori Hirashima
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京ステーションコンファレンス(東京都)
    • Year and Date
      2011-12-09
  • [Presentation] 体液調節異常と胎生期浮腫をきたす遺伝子変異マウスの解析2010

    • Author(s)
      平島正則
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2010-10-29
  • [Presentation] VEGF-A receptors in lymphatic vessel development and fluid homeostasis2010

    • Author(s)
      Masanori Hirashima
    • Organizer
      2010 International Cancer Biology Symposium
    • Place of Presentation
      国立中山大学(台湾)
    • Year and Date
      2010-06-28
  • [Presentation] 体液調節異常と胎生期浮腫をきたす遺伝子変異マウスの解析2010

    • Author(s)
      平島正則
    • Organizer
      第34回日本リンパ学会総会「シンポジウム・リンパ管新生の最前線」
    • Place of Presentation
      東京大学山上会館(東京都)
    • Year and Date
      2010-06-26
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/vascul/index.html

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Published: 2014-08-29  

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