2012 Fiscal Year Final Research Report
Pathology and molecular mechanism of embryonic edema in mice carrying endothelial gene mutations
| Project/Area Number |
22590173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MORIWAKI Kazumasa 神戸大学, 大学院・医学研究科, グローバルCOE 研究員 (00467656)
DING Guo 神戸大学, 大学院・医学研究科, グローバルCOE 研究員 (00514697)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発生学 / 形態形成学 |
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| Research Abstract |
We analyzed vascular permeability and development of the heart, blood vessels, and lymphatic vessels in Aspp1-/- and Flt1+/- mice showing embryonic edema. Lymphatic vascular development is defective in Aspp1-/- embryos, whereas vascular permeability is enhanced in Flt1+/- embryos with enhancement ofFlk1 phosphorylation. Transmission electron microscopic analysis reveals an intricateluminal surface and huge vesicle-like structures in Flt1+/- capillary endothelial cells,suggesting a promoted transcellular transport. Our analysis also shows that defectivelymphatic vessels and enhanced vascular permeability cause embryonic lethality of Aspp1-/-;Flt1+/- mice.
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