2012 Fiscal Year Final Research Report
Regulation of cellular behavior of cranial neural crest during medial cartilage formation of the skull base
| Project/Area Number |
22590182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
WADA Naoyuki 東京理科大学, 理工学部, 准教授 (50267449)
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| Co-Investigator(Kenkyū-buntansha) |
NICHIMATSU Shin-ichiro 川崎医科大学, 医学部, 講師 (20222185)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 顎顔面発生 / 頭蓋底軟骨 / 神経堤細胞 / 発生系譜 / 糖鎖 |
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| Research Abstract |
In this project, we analyzed the developmental origin of the prechordal chondrocranium, which act as the skull base in the head and midline skeleton in the face, and also investigated molecules that are involved in formation of the chondrocranium. By fate map analysis of cranial neural crest cells, the prechodal cranium is composed from three elements, the paired lateral cartilages, and the single medial cartilage. During medial cartilage formation, Foxd3, a transcription factor which regulates neural crest differentiation, was expressed in precursor cells of the cartilage. In addition, cells in the medial cartilage also expressed a carbohydrate chain, which is detected by peanut lectin (PNA). By contrast, expression of PNA-positive molecules on cells in the lateral cartilage was weak. These results suggest that the cells in the medial cartilage have distinct cellular properties from cells in the lateral cartilage.
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[Journal Article] Combinatorial roles for BMPs and endothelin 1 in patterning the dorso-ventral axis of the craniofacial skeleton.2011
Author(s)
Alexander, C., Zuniga, E., Blitz, I. L.Wada, N., LePabic, P., Javidan, Y., Zhang, T., Cho, K. W., Crump, J. G., Schilling, T. F.
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Journal Title
Development
Volume: 138
Pages: 5135-5146.
Peer Reviewed
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