2012 Fiscal Year Final Research Report
Analysis of the mechanism of blood cell- and bone marrow-derivedcell-induced separation of the blood and lymphatic vasculature
| Project/Area Number |
22590187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ICHISE Taeko 東京大学, 医科学研究所, 助教 (00396863)
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| Co-Investigator(Kenkyū-buntansha) |
ICHISE Hirotake 東京大学, 医科学研究所, 助教 (10313090)
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| Project Period (FY) |
2010 – 2012
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| Keywords | リンパ管 / PLC-gamma2 / VEGFR-3 / Cre/loxP / マウス |
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| Research Abstract |
We have previously demonstrated that PLC?2 plays an essential role in initiating and maintaining the separation of the blood and lymphatic vasculature. To further investigate the PLC?2-mediated mechanism by which lymphatic vessels are separated from blood vessels, we generated genetically engineered mice expressing PLC?2 in cell type-specific, Cre/loxP-dependent manners. Using the mice, we obtained results suggesting that megakaryocytes might play a central role in the vascular separation.
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[Journal Article] Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells2012
Author(s)
Osada, M., Inoue, O., Ding, G., Shirai, T., Ichise, H., Hirayama, K., Takano, K., Yatomi, Y., Hirashima, M., Fujii, H., Suzuki-Inoue, K., Ozaki, Y.
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Journal Title
The Journal of biological chemistry
Volume: 287
Pages: 22241-22252
DOI
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[Journal Article] Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive Dishevelled protein2010
Author(s)
Funato, Y., Terabayashi, T., Sakamoto, R., Okuzaki, D., Ichise, H., Nojima, H., Yoshida, N., Miki, H.
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Journal Title
Current biology
Volume: 20
Pages: 1945-1952
DOI
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[Journal Article] Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88)2010
Author(s)
Hayashi, T., Funato, Y., Terabayashi, T., Morinaka, A., Sakamoto, R., Ichise, H., Fukuda, H., Yoshida, N., Miki, H.
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Journal Title
The Journal of biological chemistry
Volume: 285
Pages: 18586-18593
DOI
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