2012 Fiscal Year Final Research Report
Analysis of the transcriptional regulation of gametogenesis involving SOHLH proteins
| Project/Area Number |
22590190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞分化 / 組織形成 |
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| Research Abstract |
bHLH proteins, SOHLH2 and SOHLH1, are expressed specifically in spermatogonia and oocytes, and are required for the early spermatogonial and oocyte differentiation. We demonstrated that SOHLH2 and SOHLH1 could form a heterodimerand that the SOHLH2/SOHLH1 heterodimer could up-regulate the Sohlh1 gene through its E-boxes. Subsequent studies suggested that SOHLH2/SOHLH1/SP1 ternary complex autonomously and cooperatively regulates the Sohlh1 gene transcription during early spermatogenesis and oogenesis.
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