2012 Fiscal Year Final Research Report
Histochemical studies on the expression patterns and dynamical changes of carbohydrates
| Project/Area Number |
22590193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞組織化学 |
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| Research Abstract |
More than fifty kinds of lectins and sugar-specific monoclonal antibodies were histochemically applied to various kinds of human and mouse tissue specimens. Organ-specific distribution of sugar moieties were demonstrated on both parenchymal cells and vascular endothelial cells. Specific distribution of endothelial cell surface carbohydrates might be an important clue to explain the mechanisms of organ-specific cancer metastasis. Specific distribution of glycolipids were also demonstrated on rat cerebrum, small intestine and kidney under various pathological states including diabetes. Histochemical approaches revealed important aspects of the dynamic changes of sugar expression on various tissues and cells.
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Research Products
(24 results)
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[Journal Article] Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-RaMP2 system2013
Author(s)
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Schido Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Hindo T
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Journal Title
Hypertension
Volume: 61
Pages: 341-351
DOI
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[Journal Article] Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis2013
Author(s)
Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Schindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH,Kawakami H, Mochizuki N, Martinez A, Shindo T
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Journal Title
Circulation
Volume: 127
Pages: 842-853
DOI
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[Journal Article] Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARgamma-dependent nongenomic signaling2011
Author(s)
Endo Y, Suzuki M, Yamada H, Horita S, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T
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Journal Title
Cell Metab
Volume: 13
Pages: 550-561
DOI
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[Journal Article] Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): Efficient uptake and presentation of glycosylated antigens by dendritic cells2010
Author(s)
Denda-Nagai K, Aida S, Saba K, SuzukiK, Moriyama S, Oo-puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T
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Journal Title
J Biol Chem
Volume: 285
Pages: 19193-19204
DOI
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