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2012 Fiscal Year Final Research Report

Histological analysis of T cell differentiation process based on hypermulticolor-hypersensitive fluorescence imaging method

Research Project

  • PDF
Project/Area Number 22590194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionJuntendo University

Principal Investigator

TSURUI Hiromichi  順天堂大学, 医学部, 助教 (40217386)

Project Period (FY) 2010 – 2012
Keywords画像分光 / 半導体色素 / サイトカインネットワーク / 超高感度蛍光イメージング / 分化特異的転写因子 / 細胞分化・組織形成
Research Abstract

As the methods to evaluate chromophore-antibody conjugation state, gel-filtration chromatography, fluorescence-correlation spectroscopy, hyper-sensitive spectral imaging and high-magnification SEM were established or applied. Through those methods, two conjugation methods were established and applied to simultaneous imaging of T -bet, GATA-3, ROR-gt, FoxP3. IL-10 and IFN-a were also successfully imaged.

  • Research Products

    (7 results)

All 2013 2012 2011 2010

All Journal Article (6 results) Book (1 results)

  • [Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013

    • Author(s)
      Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
    • Journal Title

      mice.

      Volume: 43 Pages: 770-778

    • DOI

      DOI:10.1002/eji.201243057

  • [Journal Article] Lissencephaly with marked ventricular dilation, agenesis of corpus callosum2013

    • Author(s)
      Akihisa Okumura , Masaharu Hayashi, Hiromichi Tsurui, Yoko Yamakawa, Shinpei Abe, Takahiro Kudo, Ryuyo Suzuki, Toshiaki Shimizu, Keiko Shimojima, Toshiyuki Yamamoto
    • Journal Title

      and cerebellar hypoplasia caused by TUBA1A mutation Brain and Developoment

      Volume: Vol35 Issue 3 Pages: 274-279

    • DOI

      DOI:10.1016/j.braindev.2012.05.006

  • [Journal Article] Transgenic overexpression of G5PR that is normally augmented in centrocytes impairsthe enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice2012

    • Author(s)
      hi H, Ohtsuji M, Tsurui H, Hirose S, and Sakaguchi N
    • Journal Title

      J. Immunol

      Volume: 189 Pages: 1193-1201

    • DOI

      DOI:10.4049/jimmunol.1102774

  • [Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcy receptor type Iib-deficient C57BL/6 genetic background.2011

    • Author(s)
      Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
    • Journal Title

      Arthritis & Rheumatism

      Volume: 63 Pages: 2930-2938

    • DOI

      DOI:10.1002/art.30485

  • [Journal Article] Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus2010

    • Author(s)
      Lin Q Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S
    • Journal Title

      J Autoimmunity

      Volume: 34 Pages: 356-363

    • DOI

      DOI:10.1016/j.jaut.2009.08.011

  • [Journal Article] FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice2010

    • Author(s)
      Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 394 Pages: 804-810

    • DOI

      DOI:10.1016/j.bbrc.2010.03.078

  • [Book] Molecular Dynamics - Studies of Synthetic and Biological Macromolecules2012

    • Author(s)
      TSURUI H and TAKAHASHI T.
    • Publisher
      InTech

URL: 

Published: 2014-08-29  

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