2012 Fiscal Year Final Research Report

Analysis of microvillous formation mechanism and cell adhesion regulation by mucin-type glycoproteins

Research Project

Project/Area Number	22590198
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General anatomy (including Histology/Embryology)
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	TACHIBANA Kouichi 独立行政法人産業技術総合研究所, 健康工学部門, 主任研究員 (80216986)
Project Period (FY)	2010 – 2012
Keywords	ムチン型糖蛋白質 / 細胞接着 / 微絨毛 / ERM 蛋白質 / リン酸化 / 細胞骨格 / 細胞球状化
Research Abstract	We found expression of leukocyte surface mucin such as CD43 or CD34 resulted in microvillus formation and spherical cell shape in HEK293T cells. These phenomena were induced by the inhibition of cell adhesion by mucins via activation of ERM proteins. Mean