2012 Fiscal Year Final Research Report
Functional role of the transient receptor potential canonical (TRPC) channels in the development of cardiac ischemia/reperfusion injury
| Project/Area Number |
22590205
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Akiko 滋賀医科大学, 医学部, 助教 (50447877)
OMATSU Mariko 滋賀医科大学, 医学部, 准教授 (80161397)
DING Wei-guang 滋賀医科大学, 医学部, 助教 (80242973)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 |
|---|
| Research Abstract |
Ca2+overload has been implicated in the pathogenesis of ischemia/reperfusion injury in the heart. The present investigation used Langendorff perfusion method of mouse hearts and fluorescence Ca2+imaging of mouse ventricular myocytes and revealed that the transient receptor potential canonical (TRPC) channels mediate the Ca2+entry responsible for Ca2+overload during the reperfusion of ischemic myocardium. These observations indicate that TRPC channel blockade could provide potential new avenues to develop strategies for protecting the heart during reperfusion of ischemic myocardium.
|
-
-
-
-
-
-
-
-
[Journal Article] Phenotype Variability in Patients Carrying KCNJ2 Mutations2012
Author(s)
Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding W-G, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang W-J, Ito M, Matsuura H, Horie M
-
Journal Title
Circ Cardiovasc Genet
Volume: 5
Pages: 344-353
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation2011
Author(s)
Ohno S, Zankov DP, Ding W-G, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M
-
Journal Title
Circ Arrhythm Electrophysiol
Volume: 4
Pages: 352-361
Peer Reviewed
-
-
[Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability.2011
Author(s)
Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, Hiraoka M, Hisatome I
-
Journal Title
Circ Res
Volume: 108
Pages: 458-468
Peer Reviewed
-
-
-
[Journal Article] Atrioventricular block-induced Torsades de Pointeswith clinical and molecular backgrounds similar to congenital long QT syndrome2011
Author(s)
Oka Y, Itoh H, Ding W-G, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M
-
Journal Title
Circ J
Volume: 74
Pages: 2562-2571
Peer Reviewed
-
-
-
-
-
[Journal Article] KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.2010
Author(s)
Wu J, Shimizu W, Ding W-G, Ohno S, Toyoda F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M
-
Journal Title
Heart Rhythm
Volume: 7
Pages: 199-205
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] Novel KCNQ1 missense mutation associated with juvenile-onset atrial fibrillation2012
Author(s)
Hasegawa K, Ohno S, Itoh H, Hattori T, Makiyama T, Toyoda F, Ding W-G, Chinushi M, Matsuura H, Horie M
Organizer
American Heart Association Annual Meeting
Place of Presentation
Los Angels, USA
Year and Date
20121103-07
-
-
-
-
-
-
-
-
-
