2012 Fiscal Year Final Research Report
Analysis of vascular remodeling by t-PA/t-PAR system
| Project/Area Number |
22590219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
MATSUO Osamu 近畿大学, 医学部, 顧問 (40030879)
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| Co-Investigator(Kenkyū-buntansha) |
UESHIMA Shigeru 近畿大学, 農学部, 教授 (30193791)
OKADA Kiyotaka 近畿大学, 医学部, 講師 (20185432)
KAWAO Naoyuki 近畿大学, 医学部, 助教 (70388510)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Nobuyuki 長浜バイオ大学, アニマルバイオサイエンス学科, 教授 (90260281)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血液凝固 / 血液レオロジー |
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| Research Abstract |
t-PAR-transfected endothelial cells enhanced the t-PA binding ability, t-PA-mediated plasminogen activation, migration and invasion of cells, and tube formation as compared with control endothelial cells. Vascular smooth muscle cells bound to t-PA and enhanced t-PA-mediated plasminogen activation. Therefore, it is thought that t-PA/t-PAR system on the membrane surface of these cells plays an important role on the tissue regeneration process.
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[Journal Article] Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo.2012
Author(s)
Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O.
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Journal Title
Thromb Haemost
Volume: 107
Pages: 749-59
DOI
Peer Reviewed
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[Journal Article] Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.2011
Author(s)
Kanno Y, Ishisaki A, Kawashita E, Chosa N, Nakajima K, Nishihara T, Toyoshima K, Okada K, Ueshima S, Matsushita K, Matsuo O, Matsuno H.
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Journal Title
J Biol Chem
Volume: 286
Pages: 8952-8960
DOI
Peer Reviewed
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