2013 Fiscal Year Final Research Report
Physiological role of circadian clock in the ovary
| Project/Area Number |
22590220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Atsushi 電気通信大学, 情報理工学部, 助教 (50361829)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 生物リズム / 概日時計 / 卵巣 / 末梢時計 / 排卵 |
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| Research Abstract |
Circadian clock are found in most of the peripheral tissues of animals. However, the physiological roles of the clocks in peripheral tissues are yet to be shown. We hypothesized that ovarian circadian clock regulates the responsiveness of ovarian cells to LH and play a role in controlling the timing of ovulation. First, we expand our previous experiment to show the role of LH in resetting phase of circadian clock in vitro to in vivo, and obtained the consistent results. Next, molecular biological methods were employed to evaluate the hypothesis in rat ovarian granulose cells. However, it was difficult to collect sufficient cells. Therefore, cell lines established from ovarian granulose cells were used in further experiments.
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[Book] Suprachiasmatic nucleus: Cellular clocks and networks. In: The Neurobiology of Circadian Timing Kalsbeek A., Merrow M.,Ronnerberg T., Foster R.G. Eds.2012
Author(s)
Honma S., Ono D., Suzuki Y., Inagaki N.,Yoshikawa T., Nakamura W., Honma K-i.
Total Pages
129-141
Publisher
Elsevier, Progress in Brain Research 199
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