2012 Fiscal Year Final Research Report
Study on oxidative stress and the metabolism of vitamin C using "mouse having biosynthetic capability of vitamin C"
| Project/Area Number |
22590221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroyuki 金沢大学, 医学系, 教授 (30231476)
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
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| Co-Investigator(Renkei-kenkyūsha) |
HIBINO Yuri 金沢大学, 医学系, 助教 (40362008)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 酸化ストレス / ビタミンC / 抗酸化物質 / 生理学 / 栄養学 |
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| Research Abstract |
The changes in plasma ascorbate (AsA) and plasma total antioxidant capacity (TAC) induced by oxidative stress in mouse, which can biosynthesize vitamin C unlike human being, are not fully elucidated. The acute inflammation mouse model and the chronic inflammation mouse model were developed and the change in plasma AsA and plasma TAC were examined using them. The results showed that mouse could increase plasma AsA and plasma TAC against the physiological demand of vitamin C, which was increased by inflammatory reaction, in a short time
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[Journal Article] besity and aspirin intolerance are risk factors for difficult-to-treat asthmain Japanese non-atopic women2012
Author(s)
Fukutomi Y, Taniguchi M, Tsuburai T,Tanimoto H, Oshikata C, Ono E, Sekiya K, Higashi N, Mori A, Hasegawa M, Nakamura H, Akiyama K
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Journal Title
ClinExp Allergy
Volume: 42
Pages: 738-746
DOI
Peer Reviewed
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[Journal Article] Association between body mass index and asthma among Japanese adult: risk within normal weight range2012
Author(s)
Fukutomi Y, Taniguchi M, Nakamura H, Konno S, Nishimura M, Kawagishi Y, Okada C, Tanimoto Y, Takahashi K,Akasawa A, Akiyama K.
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Journal Title
Int Arch Allergy Immunol
Volume: 57
Pages: 281-287
DOI
Peer Reviewed
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[Journal Article] Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy2012
Author(s)
Fukutomi Y, Sjolander S, Nakazawa T, Borres MP, Ishii T, Nakayama S, Tanaka A, Taniguchi M, Saito A, Yasueda H, Nakamura H, Akiyama K
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Journal Title
J Allergy Clin Immunol
Volume: 129
Pages: 860-863
DOI
Peer Reviewed
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 61
Pages: 57-63
DOI
Peer Reviewed
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[Journal Article] benzene-induced allergic dermatitis in vivo," Ann Allergy Asthma Immunol Suganuma N. "Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum,on 2,4,6-trinitrochloro benzene-induced allergic dermatitis in vivo2012
Author(s)
Ngatu NR, Okajima MK, Yokogawa M, Hirota R, Eitoku M, Muzembo BA, Dumavibhat N, Takaishi M, Sano S, Kaneko T, Tanaka T
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Journal Title
Ann Allergy Asthma Immunol
Volume: 108
Pages: 117-122
DOI
Peer Reviewed
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[Journal Article] Time trend in the prevalence of adult asthma in Japan: findings from population-based surveys in Fujieda city in 1985, 1999, and 20062011
Author(s)
Fukutomi Y, Taniguchi M, Watanabe J, Nakamura H, Komase Y, Ohta K, Akasawa A, Nakagawa T, Miyamoto T, Akiyama K.
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Journal Title
Allergol Int
Volume: 60
Pages: 443-448
DOI
Peer Reviewed
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