2012 Fiscal Year Final Research Report
The role andmechanism of central AMPK on sleep homeostasis and body temperature regulation
| Project/Area Number |
22590224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SEI Hiroyoshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40206602)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 睡眠 / ホメオスタシス / AMPK / PPAR |
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| Research Abstract |
AMPK, a cellular energy sensor, is activated by 6-hour sleep deprivation. Intra cerebro ventricular injection of AICAR, an enhancer of AMPK, induces the enhancement of EEG slow wave acticity (SWA) during NREM sleep, while compound C, an inhibitor of AMPK, induces suppression of SWA. These data indicate the involvement of AMPK on sleep homeostasis. However, the activation of AMPK caused by starvation do not change the EEG SWA. Furthermore, in PPARa KO mice, above-mentioned AMPK-related drugs do not work, suggesting that the role of AMPK on the sleep homeostasis needs PPARa function.
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